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Use of Online Recruitment Strategies in a Randomized Trial of Cancer Survivors

Overview
Journal Clin Trials
Publisher Sage Publications
Date 2018 Jan 25
PMID 29361843
Citations 37
Authors
Affiliations
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Abstract

Background/aims: Despite widespread Internet adoption, online advertising remains an underutilized tool to recruit participants into clinical trials. Whether online advertising is a cost-effective method to enroll participants compared to other traditional forms of recruitment is not known.

Methods: Recruitment for the Survivorship Promotion In Reducing IGF-1 Trial, a community-based study of cancer survivors, was conducted from June 2015 through December 2016 via in-person community fairs, advertisements in periodicals, and direct postal mailings. In addition, "Right Column" banner ads were purchased from Facebook to direct participants to the Survivorship Promotion In Reducing IGF-1 Trial website. Response rates, costs of traditional and online advertisements, and demographic data were determined and compared across different online and traditional recruitment strategies. Micro-trials optimizing features of online advertisements were also explored.

Results: Of the 406 respondents to our overall outreach efforts, 6% (24 of 406) were referred from online advertising. Facebook advertisements were shown over 3 million times (impressions) to 124,476 people, which resulted in 4401 clicks on our advertisement. Of these, 24 people ultimately contacted study staff, 6 underwent prescreening, and 4 enrolled in the study. The cost of online advertising per enrollee was $794 when targeting a general population versus $1426 when accounting for strategies that specifically targeted African Americans or men. By contrast, community fairs, direct mail, or periodicals cost $917, $799, or $436 per enrollee, respectively. Utilization of micro-trials to assess online ads identified subtleties (e.g. use of an advertisement title) that substantially impacted viewer interest in our trial.

Conclusion: Online advertisements effectively directed a relevant population to our website, which resulted in new enrollees in the Survivorship Promotion In Reducing IGF-1 Trial at a cost comparable to traditional methods. Costs were substantially greater with online recruitment when targeting under-represented populations, however. Additional research using online micro-trial tools is needed to evaluate means of more precise recruitment to improve yields in under-represented groups. Potential gains from faster recruitment speed remain to be determined.

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References
1.
Jones R, Goldsmith L, Hewson P, Williams C . Recruitment to online therapies for depression: pilot cluster randomized controlled trial. J Med Internet Res. 2013; 15(3):e45. PMC: 3636297. DOI: 10.2196/jmir.2367. View

2.
Nash E, Gilroy D, Srikusalanukul W, Abhayaratna W, Stanton T, Mitchell G . Facebook advertising for participant recruitment into a blood pressure clinical trial. J Hypertens. 2017; 35(12):2527-2531. DOI: 10.1097/HJH.0000000000001477. View

3.
Kunz R, Vist G, Oxman A . Randomisation to protect against selection bias in healthcare trials. Cochrane Database Syst Rev. 2007; (2):MR000012. DOI: 10.1002/14651858.MR000012.pub2. View

4.
Graham A, Milner P, Saul J, Pfaff L . Online advertising as a public health and recruitment tool: comparison of different media campaigns to increase demand for smoking cessation interventions. J Med Internet Res. 2008; 10(5):e50. PMC: 2630839. DOI: 10.2196/jmir.1001. View

5.
Ashery R, McAuliffe W . Implementation issues and techniques in randomized trials of outpatient psychosocial treatments for drug abusers: recruitment of subjects. Am J Drug Alcohol Abuse. 1992; 18(3):305-29. DOI: 10.3109/00952999209026069. View