Development of a Real-time and Quantitative Thrombus Sensor for an Extracorporeal Centrifugal Blood Pump by Near-infrared Light

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2018 Jan 24

PMID 29359096

Citations 2

Authors

Daisuke Sakota

Tatsuki Fujiwara

Katsuhiro Ohuchi

Katsuyuki Kuwana

Hiroyuki Yamazaki

Ryo Kosaka

Masahiro Nishida

Tomohiro Mizuno

Hirokuni Arai

Osamu Maruyama

Affiliations

Soon will be listed here.

Abstract

We developed an optical thrombus sensor for a monopivot extracorporeal centrifugal blood pump. In this study, we investigated its quantitative performance for thrombus detection in acute animal experiments of left ventricular assist using the pump on pathogen-free pigs. Optical fibers were set in the driver unit of the pump. The incident light at the near-infrared wavelength of 810 nm was aimed at the pivot bearing, and the resulting scattered light was guided to the optical fibers. The detected signal was analyzed to obtain the thrombus formation level. As a result, real-time and quantitative monitoring of the thrombus surface area on the pivot bearing was achieved with an accuracy of 3.6 ± 2.3 mm. In addition, the sensing method using the near-infrared light was not influenced by changes in the oxygen saturation and the hematocrit. It is expected that the developed sensor will be useful for optimal anticoagulation management for long-term extracorporeal circulation therapies.

Citing Articles

Prevention of thrombus formation in blood pump by mechanical circular orbital excitation of impeller in magnetically levitated centrifugal pump.

Hatakenaka K, Hijikata W, Fujiwara T, Ohuchi K, Inoue Y Artif Organs. 2022; 47(2):425-431.

PMID: 36305737 PMC: 10098525. DOI: 10.1111/aor.14443.

Real-time, non-invasive thrombus detection in an extracorporeal circuit using micro-optical thrombus sensors.

Morita N, Sakota D, Oota-Ishigaki A, Kosaka R, Maruyama O, Nishida M Int J Artif Organs. 2020; 44(8):565-573.

PMID: 33300399 PMC: 8366175. DOI: 10.1177/0391398820978656.

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