The Hypoxia-Adenosine Link During Intestinal Inflammation

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2018 Jan 24

PMID 29358413

Citations 38

Authors

Jessica L Bowser

Luan H Phan

Holger K Eltzschig

Affiliations

Soon will be listed here.

Abstract

Intestinal inflammation is a key element in inflammatory bowel disease and is related to a combination of factors, including genetics, mucosal barrier dysfunction, bacteria translocation, deleterious host-microbe interactions, and dysregulated immune responses. Over the past decade, it has been appreciated that these inflammatory lesions are associated with profound tissue hypoxia. Interestingly, an endogenous adaptive response under the control of hypoxia signaling is enhancement in adenosine signaling, which impacts these different endpoints, including promoting barrier function and encouraging anti-inflammatory activity. In this review, we discuss the hypoxia-adenosine link in inflammatory bowel disease, intestinal ischemia/reperfusion injury, and colon cancer. In addition, we provide a summary of clinical implications of hypoxia and adenosine signaling in intestinal inflammation and disease.

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