Regulation of Mammalian DNA Replication Via the Ubiquitin-Proteasome System

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2018 Jan 23

PMID 29357069

Citations 14

Authors

Tarek Abbas

Anindya Dutta

Affiliations

Soon will be listed here.

Abstract

Proper regulation of DNA replication ensures the faithful transmission of genetic material essential for optimal cellular and organismal physiology. Central to this regulation is the activity of a set of enzymes that induce or reverse posttranslational modifications of various proteins critical for the initiation, progression, and termination of DNA replication. This is particularly important when DNA replication proceeds in cancer cells with elevated rates of genomic instability and increased proliferative capacities. Here, we describe how DNA replication in mammalian cells is regulated via the activity of the ubiquitin-proteasome system as well as the consequence of derailed ubiquitylation signaling involved in this important cellular activity.

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References

Moldovan G, DAndrea A . DNA damage discrimination at stalled replication forks by the Rad5 homologs HLTF and SHPRH. Mol Cell. 2011; 42(2):141-3. DOI: 10.1016/j.molcel.2011.03.018. View

Fujimitsu K, Grimaldi M, Yamano H . Cyclin-dependent kinase 1-dependent activation of APC/C ubiquitin ligase. Science. 2016; 352(6289):1121-4. DOI: 10.1126/science.aad3925. View

Soucy T, Smith P, Milhollen M, Berger A, Gavin J, Adhikari S . An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature. 2009; 458(7239):732-6. DOI: 10.1038/nature07884. View

Kaur M, Khan M, Kar A, Sharma A, Saxena S . CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10. Nucleic Acids Res. 2012; 40(15):7332-46. PMC: 3424545. DOI: 10.1093/nar/gks366. View

Liu E, Li X, Yan F, Zhao Q, Wu X . Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J Biol Chem. 2004; 279(17):17283-8. DOI: 10.1074/jbc.C300549200. View

Donzelli M, Squatrito M, Ganoth D, Hershko A, Pagano M, Draetta G . Dual mode of degradation of Cdc25 A phosphatase. EMBO J. 2002; 21(18):4875-84. PMC: 126287. DOI: 10.1093/emboj/cdf491. View

Kanke M, Kodama Y, Takahashi T, Nakagawa T, Masukata H . Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. EMBO J. 2012; 31(9):2182-94. PMC: 3343466. DOI: 10.1038/emboj.2012.68. View

Zhao Y, Morgan M, Sun Y . Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy. Antioxid Redox Signal. 2014; 21(17):2383-400. PMC: 4241876. DOI: 10.1089/ars.2013.5795. View

Jung Y, Liu G, Chen X . Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation. Mol Cell Biol. 2009; 30(4):1041-8. PMC: 2815560. DOI: 10.1128/MCB.01198-09. View

10.

Nawrocki S, Griffin P, Kelly K, Carew J . MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy. Expert Opin Investig Drugs. 2012; 21(10):1563-73. DOI: 10.1517/13543784.2012.707192. View

11.

Clijsters L, Wolthuis R . PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase. J Cell Sci. 2014; 127(Pt 6):1336-45. DOI: 10.1242/jcs.145862. View

12.

Qing P, Han L, Bin L, Yan L, Ping W . USP7 regulates the stability and function of HLTF through deubiquitination. J Cell Biochem. 2011; 112(12):3856-62. DOI: 10.1002/jcb.23317. View

13.

Unk I, Hajdu I, Fatyol K, Hurwitz J, Yoon J, Prakash L . Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination. Proc Natl Acad Sci U S A. 2008; 105(10):3768-73. PMC: 2268824. DOI: 10.1073/pnas.0800563105. View

14.

Gallego-Sanchez A, Andres S, Conde F, San-Segundo P, Bueno A . Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae. PLoS Genet. 2012; 8(7):e1002826. PMC: 3400564. DOI: 10.1371/journal.pgen.1002826. View

15.

Aparicio O, Weinstein D, Bell S . Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell. 1997; 91(1):59-69. DOI: 10.1016/s0092-8674(01)80009-x. View

16.

Thu Y, Bielinsky A . Enigmatic roles of Mcm10 in DNA replication. Trends Biochem Sci. 2013; 38(4):184-94. PMC: 3608807. DOI: 10.1016/j.tibs.2012.12.003. View

17.

Di Fiore B, Pines J . Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C. J Cell Biol. 2007; 177(3):425-37. PMC: 2064829. DOI: 10.1083/jcb.200611166. View

18.

Vaziri C, Saxena S, Jeon Y, Lee C, Murata K, Machida Y . A p53-dependent checkpoint pathway prevents rereplication. Mol Cell. 2003; 11(4):997-1008. DOI: 10.1016/s1097-2765(03)00099-6. View

19.

Lin J, Zeman M, Chen J, Yee M, Cimprich K . SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis. Mol Cell. 2011; 42(2):237-49. PMC: 3080461. DOI: 10.1016/j.molcel.2011.02.026. View

20.

Alexandrow M, Hamlin J . Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A. Mol Cell Biol. 2004; 24(4):1614-27. PMC: 344196. DOI: 10.1128/MCB.24.4.1614-1627.2004. View