Oncohistones: Drivers of Pediatric Cancers

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2018 Jan 21

PMID 29352018

Citations 59

Authors

Faizaan Mohammad

Kristian Helin

Affiliations

Soon will be listed here.

Abstract

One of the most striking results in the area of chromatin and cancer in recent years has been the identification of recurrent mutations in histone genes in pediatric cancers. These mutations occur at high frequency and lead to the expression of mutant histones that exhibit oncogenic features. Thus, they are termed oncohistones. Thus far, mutations have been found in the genes encoding histone H3 and its variants. The expression of the oncohistones affects the global chromatin landscape through mechanisms that have just begun to be unraveled. In this review, we provide an overview of histone mutations that have been identified and discuss the possible mechanisms by which they contribute to tumor development. We further discuss the targeted therapies that have been proposed to treat cancers expressing oncohistones.

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