Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of and for Precocious Puberty: A Preliminary Experimental Study Using Female Rats

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2018 Jan 20

PMID 29348765

Citations 4

Authors

Tuy An Trinh

Seung Chan Park

Jihong Oh

Chang-Eop Kim

Ki Sung Kang

Hwa Seung Yoo

Hye Lim Lee

Affiliations

Soon will be listed here.

Abstract

Background: Precocious puberty is a common endocrine disease in children. Inappropriate activation of hypothalamic-pituitary-gonadal axis leads to the development of secondary sexual characteristics at an earlier age than normal children and causes short stature in adulthood.

Objectives: The aim of this study is to evaluate the preventive effects of a herbal formulation containing a mixture of and (hEIF extract) on precocious puberty.

Methods: The preventive effect of hEIF extract on precocious puberty in rats was evaluated by measuring blood component after 3 weeks of treatment via oral administration. Network pharmacological analyses were performed to predict the bioactive components of hEIF extract.

Results: studies showed that hEIF extract significantly reduced follicle stimulating hormone (FSH) levels. After treatment with 200 mg/kg of hEIF extract, the FSH level was 5.33 ± 1.10 ng/mL, whereas the FSH level in the vehicle group was 46.73 ± 0.80 ng/mL. Moreover, the use of hEIF extract did not stimulate body growth and bone accretion in rats. The network pharmacological analysis led to the identification of multiple targets of hEIF extract related to lipolysis and the female sex hormone-related pathways.

Conclusion: hEIF extract can be used as an FSH inhibitor for the treatment of precocious puberty.

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References

Nguyen D, Li Calzi S, Shaw L, Kielczewski J, Korah H, Grant M . An ocular view of the IGF-IGFBP system. Growth Horm IGF Res. 2013; 23(3):45-52. PMC: 3833084. DOI: 10.1016/j.ghir.2013.03.001. View

Biro F, Khoury P, Morrison J . Influence of obesity on timing of puberty. Int J Androl. 2005; 29(1):272-7. DOI: 10.1111/j.1365-2605.2005.00602.x. View

Thompson I, Kaiser U . GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression. Mol Cell Endocrinol. 2013; 385(1-2):28-35. PMC: 3947649. DOI: 10.1016/j.mce.2013.09.012. View

Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M . KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 2011; 40(Database issue):D109-14. PMC: 3245020. DOI: 10.1093/nar/gkr988. View

Jang S, Kim Y, Lee W, Kwak K, Baek S, Kwak G . Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma Plus LPS. Arch Pharm Res. 2005; 28(2):203-8. DOI: 10.1007/BF02977716. View

Parent A, Rasier G, Gerard A, Heger S, Roth C, Mastronardi C . Early onset of puberty: tracking genetic and environmental factors. Horm Res. 2005; 64 Suppl 2:41-7. DOI: 10.1159/000087753. View

Partsch C, Sippell W . Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens. Hum Reprod Update. 2001; 7(3):292-302. DOI: 10.1093/humupd/7.3.292. View

Kim S, Huh K, Won S, Lee K, Park M . A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010. PLoS One. 2015; 10(11):e0141844. PMC: 4634943. DOI: 10.1371/journal.pone.0141844. View

Gervasio C, Bernuci M, Silva-de-Sa M, Rosa-E-Silva A . The role of androgen hormones in early follicular development. ISRN Obstet Gynecol. 2014; 2014:818010. PMC: 4003798. DOI: 10.1155/2014/818010. View

10.

Tian Z, Zhao H, Sun Y, Cai D, Chen B . Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: therapeutic effects of nourishing "Yin"-Removing "Fire" Chinese herb mixture. Reprod Biol Endocrinol. 2005; 3:38. PMC: 1236957. DOI: 10.1186/1477-7827-3-38. View

11.

Ru J, Li P, Wang J, Zhou W, Li B, Huang C . TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 2014; 6:13. PMC: 4001360. DOI: 10.1186/1758-2946-6-13. View

12.

Carel J, Leger J . Clinical practice. Precocious puberty. N Engl J Med. 2008; 358(22):2366-77. DOI: 10.1056/NEJMcp0800459. View

13.

Kiso Y, Ogasawara S, Hirota K, Watanabe N, Oshima Y, Konno C . Antihepatotoxic principles of Artemisia capillaris buds. Planta Med. 1984; 50(1):81-5. View

14.

Berberoglu M . Precocious puberty and normal variant puberty: definition, etiology, diagnosis and current management. J Clin Res Pediatr Endocrinol. 2011; 1(4):164-74. PMC: 3005651. DOI: 10.4274/jcrpe.v1i4.3. View

15.

Massart F, Parrino R, Seppia P, Federico G, Saggese G . How do environmental estrogen disruptors induce precocious puberty?. Minerva Pediatr. 2006; 58(3):247-54. View

16.

Neely E, Crossen S . Precocious puberty. Curr Opin Obstet Gynecol. 2014; 26(5):332-8. DOI: 10.1097/GCO.0000000000000099. View

17.

Long D . Precocious Puberty. Pediatr Rev. 2015; 36(7):319-21. DOI: 10.1542/pir.36-7-319. View

18.

Shannon P, Markiel A, Ozier O, Baliga N, Wang J, Ramage D . Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003; 13(11):2498-504. PMC: 403769. DOI: 10.1101/gr.1239303. View

19.

Xu X, Zhang W, Huang C, Li Y, Yu H, Wang Y . A novel chemometric method for the prediction of human oral bioavailability. Int J Mol Sci. 2012; 13(6):6964-6982. PMC: 3397506. DOI: 10.3390/ijms13066964. View

20.

Kuo C, Chen H, Chiang W . Adlay ( yì yĭ; "soft-shelled job's tears"; the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf) is a Potential Cancer Chemopreventive Agent toward Multistage Carcinogenesis Processes. J Tradit Complement Med. 2014; 2(4):267-75. PMC: 3942904. DOI: 10.1016/s2225-4110(16)30112-2. View