An Ocular View of the IGF-IGFBP System

Overview

Journal Growth Horm IGF Res

Publisher Elsevier

Specialty Endocrinology

Date 2013 Apr 13

PMID 23578754

Citations 16

Authors

Dung V Nguyen

Sergio Li Calzi

Lynn C Shaw

Jennifer L Kielczewski

Hannah E Korah

Maria B Grant

Affiliations

Soon will be listed here.

Abstract

IGFs and their binding proteins have been shown to exhibit both protective and deleterious effects in ocular disease. Recent studies have characterized the expression patterns of different IGFBPs in retinal layers and within the vitreous. IGFBP-3 has roles in vascular protection stimulating proliferation, migration, and differentiation of vascular progenitor cells to sites of injury. IGFBP-3 increases pericyte ensheathment and shows anti-inflammatory effects by reducing microglia activation in diabetes. IGFBP-5 has recently been linked to mediating fibrosis in proliferative vitreoretinopathy but also reduces neovascularization. Thus, the regulatory balance between IGF and IGFBPs can have profound impact on target tissues. This review discusses recent findings of IGF and IGFBP expression in the eye with relevance to different retinopathies.

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