Human Colorectal Cancer-derived Mesenchymal Stem Cells Promote Colorectal Cancer Progression Through IL-6/JAK2/STAT3 Signaling

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2018 Jan 20

PMID 29348540

Citations 113

Authors

Xiaochao Zhang

Fayong Hu

Geng Li

Guodong Li

Xi Yang

Liang Liu

Rongsheng Zhang

Bixiang Zhang

Yongdong Feng

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells (MSCs) have been reported to localize in colorectal carcinomas, and participate in the formation of the tumor microenvironment. They have recently been isolated from colorectal cancer tissues, and are implicated in the growth, invasion, and metastasis of cancer cells. However, the roles and detailed mechanisms associated with human colorectal cancer-derived MSCs (CC-MSCs) have not been fully addressed. In this study, we found that CC-MSCs increased the migration and invasion of colorectal cancer cells and promoted the tumorigenesis of colorectal cancer through epithelial-to-mesenchymal transition (EMT) in vitro. We also found that CC-MSCs enhanced the growth and metastasis of colorectal cancer in vivo. Mechanistically, we determined that interleukin-6 (IL-6) was the most highly expressed cytokine in the CC-MSC conditioned medium, and promoted the progression of colorectal cancer cells through IL-6/JAK2/STAT3 signaling, which activated PI3K/AKT signaling. We used anti-IL-6 antibody to target IL-6. Collectively, these results reveal that the IL-6 secreted by CC-MSCs enhances the progression of colorectal cancer cells through IL-6/JAK2/STAT3 signaling, and could provide a novel therapeutic or preventive target.

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