ODF3B Affects the Proliferation and Apoptosis of Glioma Via the JAK/STAT Pathway

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2024 Apr 9

PMID 38590411

Authors

Xing-Zhao Luan

Su-Xin Yuan

Xiao-Jing Chen

Yu-Ru Zhou

Hua Tang

Jia-Qi Li

Gen Jiang

Lu-Xia Yang

Mao-Wen Luo

Jun-Jie Tian

Yu-Qi Wen

Wen-Yan Zhang

Li-Gang Chen

Wei Xiang

Jie Zhou

Affiliations

Soon will be listed here.

Abstract

The pathogenesis of glioma has remained unclear. In this study, it was found that high expression of the outer dense fibers of sperm tail 3B (ODF3B) in gliomas was positively correlated with the grade of glioma. The higher the grade, the worse the prognosis. ODF3B is closely related to the growth and apoptosis of glioma. In terms of mechanism, ODF3B was found to affect the proliferation and apoptosis of glioma through the JAK1 and JAK2/STAT3 pathways. ODF3B was also found to affect the growth and apoptosis of glioma . We conclude that ODF3B affects glioma proliferation and apoptosis via the JAK/STAT pathway and is a potential therapeutic target.

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