» Articles » PMID: 29344513

'In-Situ Split' Liver Resection/ALPPS - Historical Development and Current Practice

Overview
Journal Visc Med
Date 2018 Jan 19
PMID 29344513
Citations 17
Authors
Affiliations
Soon will be listed here.
Abstract

Background: Liver tumors that are extensive, multifocal, or critically located frequently require advanced techniques of liver resection including '!' - enabling liver resection in certain situations.

Methods: The development of the technique in the first and the subsequent 8 patients in the index center, and also the method's spread throughout Germany and the world were reviewed.

Results: In 2007, in the first patient, the new technique was developed intraoperatively by necessity. Due to the convincing outcome, it was deliberately applied again several months later in another patient, and thereafter (sparsely) used for liver resection for various indications. Following oral communication, the method spread throughout Germany, and later - mainly following the publication of the initial multicentric German series - very quickly disseminated worldwide. Currently, it is used for a very (if not overly) broad spectrum of indications by many hepatobiliary surgery centers.

Conclusion: In-situ split/ALPPS is a newly developed technique for liver resection, which was established for very specific situations. This method has created a hype, and is currently used rather generously by many centers worldwide.

Citing Articles

Long-Term Follow-Up of Patients with Advanced Colorectal Liver Metastasis: A Survival Analysis from the Randomized Controlled Multicenter Trial LIGRO.

Bjork D, Hasselgren K, Rosok B, Larsen P, Sparrelid E, Lindell G Ann Surg Open. 2024; 5(3):e455.

PMID: 39310365 PMC: 11415122. DOI: 10.1097/AS9.0000000000000455.


History of liver surgery.

Banerjee A, Hariharan D Clin Liver Dis (Hoboken). 2024; 23(1):e0237.

PMID: 38919867 PMC: 11199012. DOI: 10.1097/CLD.0000000000000237.


Correlation between the liver transection line localization and future liver remnant hypertrophy in associating liver partition and portal vein ligation for staged hepatectomy.

Romic I, Augustin G, Pavlek G, Kresic E Front Surg. 2024; 11:1369962.

PMID: 38860000 PMC: 11163109. DOI: 10.3389/fsurg.2024.1369962.


Single center experience with ALPPS and timing with stage 2 in patients with fibrotic/cirrhotic liver.

Hung K, Wang H, Li W, Lin Y, Wang C Updates Surg. 2024; 76(4):1213-1221.

PMID: 38494567 PMC: 11341627. DOI: 10.1007/s13304-024-01782-x.


Contemporary Surgical Management of Colorectal Liver Metastases.

Chandra P, Sacks G Cancers (Basel). 2024; 16(5).

PMID: 38473303 PMC: 10930601. DOI: 10.3390/cancers16050941.


References
1.
Pandanaboyana S, Bell R, Hidalgo E, Toogood G, Prasad K, Bartlett A . A systematic review and meta-analysis of portal vein ligation versus portal vein embolization for elective liver resection. Surgery. 2015; 157(4):690-8. DOI: 10.1016/j.surg.2014.12.009. View

2.
Olthof P, Coelen R, Wiggers J, Groot Koerkamp B, Malago M, Hernandez-Alejandro R . High mortality after ALPPS for perihilar cholangiocarcinoma: case-control analysis including the first series from the international ALPPS registry. HPB (Oxford). 2017; 19(5):381-387. PMC: 5662942. DOI: 10.1016/j.hpb.2016.10.008. View

3.
Lang S, Loss M, Benseler V, Glockzin G, Schlitt H . Long-term results after in-situ split (ISS) liver resection. Langenbecks Arch Surg. 2015; 400(3):361-9. DOI: 10.1007/s00423-015-1285-z. View

4.
Edmondson M, Sodergren M, Pucher P, Darzi A, Li J, Petrowsky H . Variations and adaptations of associated liver partition and portal vein ligation for staged hepatectomy (ALPPS): Many routes to the summit. Surgery. 2016; 159(4):1058-72. DOI: 10.1016/j.surg.2015.11.013. View

5.
Schnitzbauer A, Lang S, Goessmann H, Nadalin S, Baumgart J, Farkas S . Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg. 2012; 255(3):405-14. DOI: 10.1097/SLA.0b013e31824856f5. View