Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Jan 19

PMID 29342967

Citations 39

Authors

Xiaohan Wang

Xiao Gong

Peng Li

Daowan Lai

Ligang Zhou

Affiliations

Soon will be listed here.

Abstract

Cyclic depsipeptides (CDPs) are cyclopeptides in which amide groups are replaced by corresponding lactone bonds due to the presence of a hydroxylated carboxylic acid in the peptide structure. These peptides sometimes display additional chemical modifications, including unusual amino acid residues in their structures. This review highlights the occurrence, structures and biological activities of the fungal CDPs reported until October 2017. About 352 fungal CDPs belonging to the groups of cyclic tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-, and tridecadepsipeptides have been isolated from fungi. These metabolites are mainly reported from the genera , , , , , , , , and . They are known to exhibit various biological activities such as cytotoxic, phytotoxic, antimicrobial, antiviral, anthelmintic, insecticidal, antimalarial, antitumoral and enzyme-inhibitory activities. Some CDPs (i.e., PF1022A, enniatins and destruxins) have been applied as pharmaceuticals and agrochemicals.

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