Granulocyte-colony Stimulating Factor Controls Neural and Behavioral Plasticity in Response to Cocaine

Overview

Journal Nat Commun

Specialty Biology

Date 2018 Jan 18

PMID 29339724

Citations 41

Authors

Erin S Calipari

Arthur Godino

Emily G Peck

Marine Salery

Nicholas L Mervosh

Joseph A Landry

Scott J Russo

Yasmin L Hurd

Eric J Nestler

Drew D Kiraly

Affiliations

Soon will be listed here.

Abstract

Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to maladaptive motivation to seek and take the drug. There are currently no clinically available pharmacotherapies to treat cocaine addiction. Through a broad screen of innate immune mediators, we identify granulocyte-colony stimulating factor (G-CSF) as a potent mediator of cocaine-induced adaptations. Here we report that G-CSF potentiates cocaine-induced increases in neural activity in the nucleus accumbens (NAc) and prefrontal cortex. In addition, G-CSF injections potentiate cocaine place preference and enhance motivation to self-administer cocaine, while not affecting responses to natural rewards. Infusion of G-CSF neutralizing antibody into NAc blocks the ability of G-CSF to modulate cocaine's behavioral effects, providing a direct link between central G-CSF action in NAc and cocaine reward. These results demonstrate that manipulating G-CSF is sufficient to alter the motivation for cocaine, but not natural rewards, providing a pharmacotherapeutic avenue to manipulate addictive behaviors without abuse potential.

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