Application of Our Understanding of Pathogenesis of Herpetic Stromal Keratitis for Novel Therapy

Overview

Journal Microbes Infect

Publisher Elsevier

Specialties Allergy & Immunology
Microbiology

Date 2018 Jan 14

PMID 29329934

Citations 17

Authors

Naveen K Rajasagi

Barry T Rouse

Affiliations

Soon will be listed here.

Abstract

HSV-1 ocular infection can cause herpes stromal keratitis (SK), an immunopathological lesion. Frequent recurrences can lead to progressive corneal scaring which can result in vision impairment if left untreated. Currently, the acute and epithelial forms of SK are usually controlled using anti-viral drugs. However, chronic forms of SK which are inflammatory in nature, require the addition of a topical corticosteroid to the anti-viral treatment regimen. In this review, we highlight the essential events involved in SK pathogenesis which can be targeted for improved therapy. We also examine some approaches which can be combined with the current treatments to effectively control SK.

Citing Articles

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References

Daheshia M, Kanangat S, Rouse B . Production of key molecules by ocular neutrophils early after herpetic infection of the cornea. Exp Eye Res. 1999; 67(6):619-24. DOI: 10.1006/exer.1998.0565. View

van Velzen M, van de Vijver D, van Loenen F, Osterhaus A, Remeijer L, Verjans G . Acyclovir prophylaxis predisposes to antiviral-resistant recurrent herpetic keratitis. J Infect Dis. 2013; 208(9):1359-65. DOI: 10.1093/infdis/jit350. View

Thomas J, Gangappa S, Kanangat S, Rouse B . On the essential involvement of neutrophils in the immunopathologic disease: herpetic stromal keratitis. J Immunol. 1997; 158(3):1383-91. View

Carrasco M . Subconjunctival bevacizumab for corneal neovascularization in herpetic stromal keratitis. Cornea. 2008; 27(6):743-5. DOI: 10.1097/QAI.0b013e31815b833a. View

Bhela S, Mulik S, Gimenez F, Reddy P, Richardson R, Varanasi S . Role of miR-155 in the pathogenesis of herpetic stromal keratitis. Am J Pathol. 2015; 185(4):1073-84. PMC: 4380872. DOI: 10.1016/j.ajpath.2014.12.021. View

Yun H, Rowe A, Lathrop K, Harvey S, Hendricks R . Reversible nerve damage and corneal pathology in murine herpes simplex stromal keratitis. J Virol. 2014; 88(14):7870-80. PMC: 4097779. DOI: 10.1128/JVI.01146-14. View

Rajasagi N, Reddy P, Suryawanshi A, Mulik S, Gjorstrup P, Rouse B . Controlling herpes simplex virus-induced ocular inflammatory lesions with the lipid-derived mediator resolvin E1. J Immunol. 2010; 186(3):1735-46. PMC: 3888773. DOI: 10.4049/jimmunol.1003456. View

Knickelbein J, Hendricks R, Charukamnoetkanok P . Management of herpes simplex virus stromal keratitis: an evidence-based review. Surv Ophthalmol. 2009; 54(2):226-34. DOI: 10.1016/j.survophthal.2008.12.004. View

Gimenez F, Suryawanshi A, Rouse B . Pathogenesis of herpes stromal keratitis--a focus on corneal neovascularization. Prog Retin Eye Res. 2012; 33:1-9. PMC: 3511644. DOI: 10.1016/j.preteyeres.2012.07.002. View

10.

Chang J, Gabison E, Kato T, Azar D . Corneal neovascularization. Curr Opin Ophthalmol. 2001; 12(4):242-9. DOI: 10.1097/00055735-200108000-00002. View

11.

Suryawanshi A, Veiga-Parga T, Rajasagi N, Reddy P, Sehrawat S, Sharma S . Role of IL-17 and Th17 cells in herpes simplex virus-induced corneal immunopathology. J Immunol. 2011; 187(4):1919-30. PMC: 3150378. DOI: 10.4049/jimmunol.1100736. View

12.

Serhan C . Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014; 510(7503):92-101. PMC: 4263681. DOI: 10.1038/nature13479. View

13.

Webre J, Hill J, Nolan N, Clement C, McFerrin H, Bhattacharjee P . Rabbit and mouse models of HSV-1 latency, reactivation, and recurrent eye diseases. J Biomed Biotechnol. 2012; 2012:612316. PMC: 3467953. DOI: 10.1155/2012/612316. View

14.

Frank G, Buela K, Maker D, Harvey S, Hendricks R . Early responding dendritic cells direct the local NK response to control herpes simplex virus 1 infection within the cornea. J Immunol. 2012; 188(3):1350-9. PMC: 3292873. DOI: 10.4049/jimmunol.1101968. View

15.

Maertzdorf J, Osterhaus A, Verjans G . IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. J Immunol. 2002; 169(10):5897-903. DOI: 10.4049/jimmunol.169.10.5897. View

16.

Korn T, Bettelli E, Oukka M, Kuchroo V . IL-17 and Th17 Cells. Annu Rev Immunol. 2009; 27:485-517. DOI: 10.1146/annurev.immunol.021908.132710. View

17.

Rowe A, St Leger A, Jeon S, Dhaliwal D, Knickelbein J, Hendricks R . Herpes keratitis. Prog Retin Eye Res. 2012; 32:88-101. PMC: 3529813. DOI: 10.1016/j.preteyeres.2012.08.002. View

18.

Zhou X, Bailey-Bucktrout S, Jeker L, Bluestone J . Plasticity of CD4(+) FoxP3(+) T cells. Curr Opin Immunol. 2009; 21(3):281-5. PMC: 2733784. DOI: 10.1016/j.coi.2009.05.007. View

19.

Nagy J, Dvorak A, Dvorak H . VEGF-A and the induction of pathological angiogenesis. Annu Rev Pathol. 2007; 2:251-75. DOI: 10.1146/annurev.pathol.2.010506.134925. View

20.

He J, Neumann D, Kakazu A, Pham T, Musarrat F, Cortina M . PEDF plus DHA modulate inflammation and stimulate nerve regeneration after HSV-1 infection. Exp Eye Res. 2017; 161:153-162. PMC: 5554745. DOI: 10.1016/j.exer.2017.06.015. View