Synthesis of Cyclic Enones by Allyl-Palladium-Catalyzed α,β-Dehydrogenation

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2018 Jan 13

PMID 29327930

Citations 11

Authors

David Huang

Yizhou Zhao

Timothy R Newhouse

Affiliations

Soon will be listed here.

Abstract

The use of allyl-palladium catalysis for the one-step α,β-dehydrogenation of ketones via their zinc enolates is reported. The optimized protocol utilizes commercially available Zn(TMP) as base and diethyl allyl phosphate as oxidant. Notably, this transformation operates under salt-free conditions and tolerates a diverse scope of cycloalkanones.

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