Effect of Satureja Essential Oil Against Fertility Disorders Induced by Busulfan in Female Mice

Overview

Journal Vet Res Forum

Specialty Veterinary Medicine

Date 2018 Jan 13

PMID 29326785

Citations 5

Authors

Abbas Ahmadi

Saleh Bamohabat Chafjiri

Rajab Ali Sadrkhanlou

Affiliations

Soon will be listed here.

Abstract

Busulfan is an alkylating agent affects ovarian follicles growth by oxidative stress induction. has antioxidant effects. The aim of this study was to examine whether essential oil (SKEO) exhibits protective effects on busulfan-induced ovarian failure. Eighty-four adult female mice were divided into six groups including dimethyl sulfoxide (control), SKEO 225.00 mg kg (orally), busulfan 3.00 mg kg (orally), busulfan 36.00 mg kg (intraperitoneally), busulfan 3.00 mg kg and SKEO and busulfan 36.00 mg kg and SKEO. After 28 days, the mice were euthanized and oocytes were removed for fertilization (IVF) rate evaluation. Oocyte quantity and quality, fertilization rate and pre-implantation embryo development were daily examined with a stereo microscope in a period of 120 hr. Serum levels of estradiol and progesterone were also evaluated. Busulfan caused significant decreases in oocyte number and quality, fertilization rate, pre-implantation embryo development and embryo quality. The SKEO significantly decreased the adverse effects of busulfan. The present study indicated that SKEO can protect female fertility potential against busulfan induced damages.

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