Protective Effect of Royal Jelly on In Vitro Fertilization (IVF) in Male Mice Treated with Oxymetholone

Overview

Journal Cell J

Specialty Cell Biology

Date 2015 Oct 15

PMID 26464831

Citations 2

Authors

Ensieh Zahmatkesh

Gholamreza Najafi

Vahid Nejati

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to investigate the effects of royal jelly (RJ) on catalase, total antioxidant capacity and embryo development in adult mice treated with oxymetholone (OXM).

Materials And Methods: In this exprimental study, 32 male and 96 female adult Naval Medical Research Institute (NMRI) mice (7-9 weeks of age) with a ratio of 1:3 for fertili- zation purposes were randomly divided into 4 groups as follows: i. Control group (n=8) receiving 0.1 ml/mice saline daily by gavage for 30 day, ii. RJ group (n=8) treated with RJ at a dose of 100 mg/kg daily by gavage for 30 days, iii. OXM group (n=8) receiving OXM at the dose of 5 mg/kg daily by gavage for 30 days and iv. RJ+OXM group (n=8) receiving RJ at the dose of 100 mg/kg daily by gavage concomitant with 100 mg/kg OXM adminis- tration for 30 days.

Results: Analysis revealed a significant reduction in catalase, total antioxidant, as well as embryo development in OXM group (P<0.05). However, RJ group showed a salient recovery in the all of the above mentioned parameters and embryo toxicity.

Conclusion: The results of this study indicated a partially protective effect of RJ against OXM-induced embryo toxicity.

Citing Articles

Detrimental effects of cerium oxide nanoparticles on testis, sperm parameters quality, and in vitro fertilization in mice: An experimental study.

Hosseinalipour E, Karimipour M, Ahmadi A Int J Reprod Biomed. 2021; 19(9):801-810.

PMID: 34723059 PMC: 8548755. DOI: 10.18502/ijrm.v19i9.9712.

Effect of Satureja essential oil against fertility disorders induced by busulfan in female mice.

Ahmadi A, Bamohabat Chafjiri S, Sadrkhanlou R Vet Res Forum. 2018; 8(4):281-286.

PMID: 29326785 PMC: 5756246.

References

Lenzi A, Culasso F, Gandini L, Lombardo F, Dondero F . Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility. Hum Reprod. 1993; 8(10):1657-62. DOI: 10.1093/oxfordjournals.humrep.a137909. View

Tekatli H, Schouten N, van Dalen T, Burgmans I, Smakman N . Mechanism, assessment, and incidence of male infertility after inguinal hernia surgery: a review of the preclinical and clinical literature. Am J Surg. 2012; 204(4):503-9. DOI: 10.1016/j.amjsurg.2012.03.002. View

KLAIBER E, Henzl M, Lloyd C, SEGRE E . Corpus luteum-inhibiting action of oxymetholone. J Clin Endocrinol Metab. 1973; 36(1):142-7. DOI: 10.1210/jcem-36-1-142. View

Alen M, Reinila M, Vihko R . Response of serum hormones to androgen administration in power athletes. Med Sci Sports Exerc. 1985; 17(3):354-9. View

Cooper T, Noonan E, von Eckardstein S, Auger J, Baker H, Behre H . World Health Organization reference values for human semen characteristics. Hum Reprod Update. 2009; 16(3):231-45. DOI: 10.1093/humupd/dmp048. View

Halliwell B . How to characterize a biological antioxidant. Free Radic Res Commun. 1990; 9(1):1-32. DOI: 10.3109/10715769009148569. View

Schmidt L . Psychosocial burden of infertility and assisted reproduction. Lancet. 2006; 367(9508):379-80. DOI: 10.1016/S0140-6736(06)68117-8. View

Vicari E, Calogero A . Effects of treatment with carnitines in infertile patients with prostato-vesiculo-epididymitis. Hum Reprod. 2001; 16(11):2338-42. DOI: 10.1093/humrep/16.11.2338. View

Agarwal A, Ikemoto I, Loughlin K . Relationship of sperm parameters with levels of reactive oxygen species in semen specimens. J Urol. 1994; 152(1):107-10. DOI: 10.1016/s0022-5347(17)32829-x. View

10.

Sharma R, Agarwal A . Role of reactive oxygen species in male infertility. Urology. 1996; 48(6):835-50. DOI: 10.1016/s0090-4295(96)00313-5. View

11.

Aitken R . A free radical theory of male infertility. Reprod Fertil Dev. 1994; 6(1):19-23; discussion 23-4. DOI: 10.1071/rd9940019. View

12.

Hattori N, Nomoto H, Fukumitsu H, Mishima S, Furukawa S . Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro. Biomed Res. 2007; 28(5):261-6. DOI: 10.2220/biomedres.28.261. View

13.

Ollero M, Lopez M, Sharma R, Agarwal A, Larson K, Evenson D . Characterization of subsets of human spermatozoa at different stages of maturation: implications in the diagnosis and treatment of male infertility. Hum Reprod. 2001; 16(9):1912-21. DOI: 10.1093/humrep/16.9.1912. View

14.

Mbizvo M, Danso A . Male reproductive function: a review on sperm fertilising ability and infertility. Cent Afr J Med. 1991; 37(2):40-7. View

15.

AEBI H . Catalase in vitro. Methods Enzymol. 1984; 105:121-6. DOI: 10.1016/s0076-6879(84)05016-3. View

16.

de Melo-Martin I . On cloning human beings. Bioethics. 2002; 16(3):246-65. DOI: 10.1111/1467-8519.00284. View

17.

Kensler T, Egner P, Wang J, Zhu Y, Zhang B, Qian G . Strategies for chemoprevention of liver cancer. Eur J Cancer Prev. 2003; 11 Suppl 2:S58-64. View

18.

Renard P, Grizard G, Griveau J, Sion B, Boucher D, Le Lannou D . Improvement of motility and fertilization potential of postthaw human sperm using glutamine. Cryobiology. 1996; 33(3):311-9. DOI: 10.1006/cryo.1996.0031. View

19.

Husein M, Kridli R . Reproductive responses following royal jelly treatment administered orally or intramuscularly into progesterone-treated Awassi ewes. Anim Reprod Sci. 2002; 74(1-2):45-53. DOI: 10.1016/s0378-4320(02)00165-3. View

20.

Iwasaki A, Gagnon C . Formation of reactive oxygen species in spermatozoa of infertile patients. Fertil Steril. 1992; 57(2):409-16. DOI: 10.1016/s0015-0282(16)54855-9. View