Tissue-Resident Macrophages in Fungal Infections

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Jan 10

PMID 29312319

Citations 27

Authors

Shengjie Xu

Mari L Shinohara

Affiliations

Soon will be listed here.

Abstract

Invasive fungal infections result in high morbidity and mortality. Host organs targeted by fungal pathogens vary depending on the route of infection and fungal species encountered. infects the respiratory tract and disseminates throughout the central nervous system. infects mucosal tissues and the skin, and systemic infection in rodents has a tropism to the kidney. reaches distal areas of the lung once inhaled by the host. Across different tissues in naïve hosts, tissue-resident macrophages (TRMs) are one of the most populous cells of the innate immune system. Although they function to maintain homeostasis in a tissue-specific manner during steady state, TRMs may function as the first line of defense against invading pathogens and may regulate host immune responses. Thus, in any organs, TRMs are uniquely positioned and specifically programmed to function. This article reviews the current understanding of the roles of TRMs during major fungal infections.

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