Therapeutic Approaches for Induction of Tolerance and Immune Quiescence in Corneal Allotransplantation

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2018 Jan 8

PMID 29307015

Citations 8

Authors

Maryam Tahvildari

Afsaneh Amouzegar

William Foulsham

Reza Dana

Affiliations

Soon will be listed here.

Abstract

The cornea is the most commonly transplanted tissue in the body. Corneal grafts in low-risk recipients enjoy high success rates, yet over 50% of high-risk grafts (with inflamed and vascularized host beds) are rejected. As our understanding of the cellular and molecular pathways that mediate rejection has deepened, a number of novel therapeutic strategies have been unveiled. This manuscript reviews therapeutic approaches to promote corneal transplant survival through targeting (1) corneal lymphangiogenesis and hemangiogenesis, (2) antigen presenting cells, (3) effector and regulatory T cells, and (4) mesenchymal stem cells.

Citing Articles

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The impact of donor diabetes on corneal transplant immunity.

Blanco T, Musayeva A, Singh R, Nakagawa H, Lee S, Alemi H Am J Transplant. 2023; 23(9):1345-1358.

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Corneal Allografts: Factors for and against Acceptance.

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Time- and Stimulus-Dependent Characteristics of Innate Immune Cells in Organ-Cultured Human Corneal Tissue.

Zhuang X, Schlunck G, Wolf J, Rosmus D, Bleul T, Luo R J Innate Immun. 2021; 14(2):98-111.

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Mesenchymal stromal cells for corneal transplantation: Literature review and suggestions for successful clinical trials.

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