Development of Monocytes, Macrophages, and Dendritic Cells

Overview

Journal Science

Specialty Science

Date 2010 Feb 6

PMID 20133564

Citations 1383

Authors

Frederic Geissmann

Markus G Manz

Steffen Jung

Michael H Sieweke

Miriam Merad

Klaus Ley

Affiliations

Soon will be listed here.

Abstract

Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system. Dendritic cells initiate and regulate the highly pathogen-specific adaptive immune responses and are central to the development of immunologic memory and tolerance. Recent in vivo experimental approaches in the mouse have unveiled new aspects of the developmental and lineage relationships among these cell populations. Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated.

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