Swimming Training Alleviated Insulin Resistance Through Wnt3a/-catenin Signaling in Type 2 Diabetic Rats

Overview

Journal Iran J Basic Med Sci

Publisher Mashhad University of Medical Sciences

Specialty General Medicine

Date 2018 Jan 5

PMID 29299199

Citations 11

Authors

Qiang Yang

Wen-Wen Wang

Pu Ma

Zhong-Xuan Ma

Meng Hao

Temitope I Adelusi

Lei-Du

Xiao-Xing Yin

Qian Lu

Affiliations

Soon will be listed here.

Abstract

Objectives: Increasing evidence suggests that regular physical exercise improves type 2 diabetes mellitus (T2DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T2DM, and its underlying mechanisms remain unclear.

Materials And Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T2DM model, and subsequently treated with or without swimming exercise. An 8-week swimming program (30, 60 or 120 min per day, 5 days per week) decreased body weight, fasting blood glucose and fasting insulin.

Results: Swimming ameliorated lipid disorder, improved muscular atrophy and revealed a reduced glycogen deposit in skeletal muscles of diabetic rats. Furthermore, swimming also inhibited the activation of Wnt3a/-catenin signaling pathway, decreased Wnt3a mRNA and protein level, upregulated GSK3 phosphorylation activity and reduced the expression of β-catenin phosphorylation in diabetic rats.

Conclusion: The trend of the result suggests that swimming exercise proved to be a potent ameliorator of insulin resistancein T2DM through the modulation of Wnt3a/-catenin pathway and therefore, could present a promising therapeutic measure towards the treatment of diabetes and its relatives.

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