Human to Animal Transmission of Influenza A(H1N1)pdm09 in a Turkey Breeder Flock in Norway

Overview

Journal Infect Ecol Epidemiol

Specialty Microbiology

Date 2018 Jan 4

PMID 29296243

Citations 4

Authors

Siri Kulberg Sjurseth

Britt Gjerset

Karoline Bragstad

Olav Hungnes

Helene Wisloff

Chiek Er

Mette Valheim

Siri M Lotvedt

Bruce David

Skjalg A Hanssen

Siri H Hauge

Merete Hofshagen

Affiliations

Soon will be listed here.

Abstract

: Routine surveillance samples disclosed seropositivity to influenza A virus (IAV) in a Norwegian turkey breeder flock. Simultaneous reports of influenza-like symptoms in farm workers and a laboratory confirmed influenza A(H1N1)pdm09 (H1N1pdm09) infection in one person led to the suspicion of a H1N1pdm09 infection in the turkeys. : H1N1pdm09 infection was confirmed by a positive haemaggutinin inhibition test using H1N1pdm09 antigens, and detection of H1N1pdm09 nucleic acid in reproductive organs of turkey hens. The flock showed no clinical signs except for a temporary drop in egg production. Previous reports of H1N1pdm09 infection in turkeys suggested human-to-turkey transmission (anthroponosis) during artificial insemination. : The flock remained seropositive to IAV and the homologous H1N1pdm09 antigen throughout the following 106 days, with decreasing seroprevalence over time. IAV was not detected in fertilised eggs or in turkey poults from the farm, however, maternally derived antibodies against H1N1pdm09 were found in egg yolks and in day-old poults. Genetic analyses of haemagglutinin gene sequences from one of the infected farm workers and turkeys revealed a close phylogenetic relationship, and confirmed human-to-turkey virus transmission.

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