Design, Synthesis and Biological Evaluation of Glutamic Acid Derivatives As Anti-oxidant and Anti-inflammatory Agents

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2018 Jan 4

PMID 29295794

Citations 4

Authors

Suvarna H Pagire

Eunhye Lee

Haushabhau S Pagire

Eun Jung Bae

Soo Jung Ryu

Dahye Lee

Min Hee Kim

Geum Ran Kim

Kyu-Seok Hwang

Sukyung Ahn

Jin Hee Maeng

Jin Sook Song

Myung Ae Bae

Don Hang Lee

Jin Hee Ahn

Affiliations

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Abstract

A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.

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