Simvastatin and Nanofibrous Poly(l-lactic Acid) Scaffolds to Promote the Odontogenic Potential of Dental Pulp Cells in an Inflammatory Environment

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2018 Jan 3

PMID 29294374

Citations 28

Authors

Diana G Soares

Zhanpeng Zhang

Fatma Mohamed

Thomas W Eyster

Carlos A de Souza Costa

Peter X Ma

Affiliations

Soon will be listed here.

Abstract

Statement Of Significance: The regeneration potential of stem cells is dependent on their microenvironment. In this study, we investigated the effect of the microenvironment of dental pulp stem cells (DPSCs), including 3D structure of a macroporous and nanofibrous scaffold, the inflammatory stimulus lipopolysaccharide (LPS) and a biological molecule simvastatin, on their regenerative potential of mineralized dentin tissue. The results demonstrated that LPS upregulated inflammatory mediators and suppressed the odontogenic potential of DPSCs. Known as a lipid-lowing agent, simvastatin was excitingly found to repress the expression of pro-inflammatory mediators, up-regulate odontoblastic markers, and exert a pro-angiogenic effect on endothelial cells, resulting in enhanced vascularization and mineralized dentin tissue regeneration in a biomimetic 3D tissue engineering scaffold. This novel finding is significant for the fields of stem cells, inflammation and dental tissue regeneration.

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