Association Between Coffee or Caffeine Consumption and Fecundity and Fertility: a Systematic Review and Dose-response Meta-analysis

Overview

Journal Clin Epidemiol

Publisher Dove Medical Press

Specialty Public Health

Date 2017 Dec 26

PMID 29276412

Citations 22

Authors

Julie Lyngso

Cecilia Host Ramlau-Hansen

Bjorn Bay

Hans Jakob Ingerslev

Adam Hulman

Ulrik Schioler Kesmodel

Affiliations

Soon will be listed here.

Abstract

Objective: The aim was to investigate whether coffee or caffeine consumption is associated with reproductive endpoints among women with natural fertility (ie, time to pregnancy [TTP] and spontaneous abortion [SAB]) and among women in fertility treatment (ie, clinical pregnancy rate or live birth rate).

Design: This study was a systematic review and dose-response meta-analysis including data from case-control and cohort studies.

Methods: An extensive literature search was conducted in MEDLINE and Embase, with no time and language restrictions. Also, reference lists were searched manually. Two independent reviewers assessed the manuscript quality using the Newcastle-Ottawa Scale (NOS). A two-stage dose-response meta-analysis was applied to assess a potential association between coffee/caffeine consumption and the outcomes: TTP, SAB, clinical pregnancy, and live birth. Heterogeneity between studies was assessed using Cochrane -test and statistics. Publication bias was assessed using Egger's regression test.

Results: The pooled results showed that coffee/caffeine consumption is associated with a significantly increased risk of SAB for 300 mg caffeine/day (relative risk [RR]: 1.37, 95% confidence interval [95% CI]: 1.19; 1.57) and for 600 mg caffeine/day (RR: 2.32, 95% CI: 1.62; 3.31). No association was found between coffee/caffeine consumption and outcomes of fertility treatment (based on two studies). No clear association was found between exposure to coffee/caffeine and natural fertility as measured by fecundability odds ratio (based on three studies) or waiting TTP (based on two studies).

Conclusion: Results from this meta-analysis support the growing evidence of an association between coffee/caffeine intake and the risk of SAB. However, viewing the reproductive capacity in a broader perspective, there seems to be little, if any, association between coffee/caffeine consumption and fecundity. In general, results from this study are supportive of a precautionary principle advised by health organizations such as European Food Safety Authority (EFSA) and World Health Organization (WHO), although the advised limit of a maximum of two to three cups of coffee/200-300 mg caffeine per day may be too high.

Citing Articles

Common Beverage Consumption and Benign Gynecological Conditions.

Michel R, Hazimeh D, Saad E, Olson S, Musselman K, Elgindy E Beverages (Basel). 2024; 10(2).

PMID: 38948304 PMC: 11211953. DOI: 10.3390/beverages10020033.

Beyond body mass index: a synthesis of lifestyle factors that may influence in vitro fertilisation outcomes.

Schneider E, Hamer O, Smith C, Hill J Br J Midwifery. 2024; 31(8):436-444.

PMID: 38808077 PMC: 7616016. DOI: 10.12968/bjom.2023.31.8.436.

Examining the Role of Nutrition in Cancer Survivorship and Female Fertility: A Narrative Review.

Klobodu C, Vitolins M, Deutsch J, Fisher K, Nasser J, Stott D Curr Dev Nutr. 2024; 8(4):102134.

PMID: 38584676 PMC: 10997918. DOI: 10.1016/j.cdnut.2024.102134.

Diagnosis and management of infertility: NICE-adapted guidelines from the Italian Society of Human Reproduction.

Palomba S, Vigano P, Chamayou S, Donarelli Z, Costantini M, Marci R Reprod Biol Endocrinol. 2024; 22(1):9.

PMID: 38183116 PMC: 10768082. DOI: 10.1186/s12958-023-01179-2.

Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters: A systematic review and dose-response meta-analysis.

Saxov K, Strandberg-Larsen K, Pristed S, Bruun N, Kesmodel U Acta Obstet Gynecol Scand. 2023; 102(7):821-832.

PMID: 37221907 PMC: 10333669. DOI: 10.1111/aogs.14566.

References

Juul S, Karmaus W, Olsen J . Regional differences in waiting time to pregnancy: pregnancy-based surveys from Denmark, France, Germany, Italy and Sweden. The European Infertility and Subfecundity Study Group. Hum Reprod. 1999; 14(5):1250-4. DOI: 10.1093/humrep/14.5.1250. View

Yamazaki H, Shaw P, Guengerich F, Shimada T . Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes. Chem Res Toxicol. 1998; 11(6):659-65. DOI: 10.1021/tx970217f. View

Jensen T, Henriksen T, Hjollund N, Scheike T, Kolstad H, Giwercman A . Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy. Reprod Toxicol. 1998; 12(3):289-95. DOI: 10.1016/s0890-6238(98)00002-1. View

Durrleman S, Simon R . Flexible regression models with cubic splines. Stat Med. 1989; 8(5):551-61. DOI: 10.1002/sim.4780080504. View

Pollack A, Buck Louis G, Sundaram R, Lum K . Caffeine consumption and miscarriage: a prospective cohort study. Fertil Steril. 2009; 93(1):304-6. PMC: 2812592. DOI: 10.1016/j.fertnstert.2009.07.992. View

Caan B, Quesenberry Jr C, Coates A . Differences in fertility associated with caffeinated beverage consumption. Am J Public Health. 1998; 88(2):270-4. PMC: 1508200. DOI: 10.2105/ajph.88.2.270. View

Christianson R, OECHSLI F, VAN DEN BERG B . Caffeinated beverages and decreased fertility. Lancet. 1989; 1(8634):378. DOI: 10.1016/s0140-6736(89)91745-5. View

George L, Granath F, Johansson A, Olander B, Cnattingius S . Risks of repeated miscarriage. Paediatr Perinat Epidemiol. 2006; 20(2):119-26. DOI: 10.1111/j.1365-3016.2006.00703.x. View

Maconochie N, Doyle P, Prior S, Simmons R . Risk factors for first trimester miscarriage--results from a UK-population-based case-control study. BJOG. 2007; 114(2):170-86. DOI: 10.1111/j.1471-0528.2006.01193.x. View

10.

Fenster L, Hubbard A, Swan S, Windham G, Waller K, Hiatt R . Caffeinated beverages, decaffeinated coffee, and spontaneous abortion. Epidemiology. 1997; 8(5):515-23. DOI: 10.1097/00001648-199709000-00008. View

11.

Parazzini F, Chatenoud L, Di Cintio E, Mezzopane R, Surace M, Zanconato G . Coffee consumption and risk of hospitalized miscarriage before 12 weeks of gestation. Hum Reprod. 1998; 13(8):2286-91. DOI: 10.1093/humrep/13.8.2286. View

12.

Kline J, Levin B, Silverman J, Kinney A, Stein Z, Susser M . Caffeine and spontaneous abortion of known karyotype. Epidemiology. 1991; 2(6):409-17. DOI: 10.1097/00001648-199111000-00004. View

13.

Spinelli A, Figa-Talamanca I, Osborn J . Time to pregnancy and occupation in a group of Italian women. Int J Epidemiol. 1997; 26(3):601-9. DOI: 10.1093/ije/26.3.601. View

14.

Al-Ansary L, Babay Z . Risk factors for spontaneous abortion: a preliminary study on Saudi women. J R Soc Health. 1994; 114(4):188-93. DOI: 10.1177/146642409411400403. View

15.

Cnattingius S, Signorello L, Anneren G, Clausson B, Ekbom A, Ljunger E . Caffeine intake and the risk of first-trimester spontaneous abortion. N Engl J Med. 2000; 343(25):1839-45. DOI: 10.1056/NEJM200012213432503. View

16.

Wisborg K, Kesmodel U, Bech B, Hedegaard M, Henriksen T . Maternal consumption of coffee during pregnancy and stillbirth and infant death in first year of life: prospective study. BMJ. 2003; 326(7386):420. PMC: 149440. DOI: 10.1136/bmj.326.7386.420. View

17.

Armstrong B, McDonald A, Sloan M . Cigarette, alcohol, and coffee consumption and spontaneous abortion. Am J Public Health. 1992; 82(1):85-7. PMC: 1694397. DOI: 10.2105/ajph.82.1.85. View

18.

Lawson C, LeMasters G, Levin L, Liu J . Pregnancy hormone metabolite patterns, pregnancy symptoms, and coffee consumption. Am J Epidemiol. 2002; 156(5):428-37. DOI: 10.1093/aje/kwf035. View

19.

Chen D, Fang D, Wilson J . Meta-Analysis of Two Studies With Random Effects?. J Minim Invasive Gynecol. 2017; 24(5):689-690. DOI: 10.1016/j.jmig.2017.05.008. View

20.

Rasch V . Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion. Acta Obstet Gynecol Scand. 2003; 82(2):182-8. DOI: 10.1034/j.1600-0412.2003.00078.x. View