Updates on Corneal Collagen Cross-linking: Indications, Techniques and Clinical Outcomes

Overview

Journal J Curr Ophthalmol

Date 2017 Dec 23

PMID 29270469

Citations 25

Authors

Mehrdad Mohammadpour

Ahmad Masoumi

Masoud Mirghorbani

Kianoosh Shahraki

Hassan Hashemi

Affiliations

Soon will be listed here.

Abstract

Purpose: To review the historical background and basic principles of collagen cross-linking, to bring together the data regarding the outcomes and complications of collagen cross-linking and finally to explore the efficacy and safety of new variations of this technique.

Methods: A literature review was performed using PubMed and Scopus. The following keywords were used for literature search: cross linking, crosslinking, cross-linking, keratoconus, keratectasia.

Results: In contrast to traditional treatment modalities for keratoconus (KCN), this new technique addresses the progression of the disease. Several clinical studies have been conducted to assess the efficacy of corneal collagen cross-linking (CXL) in the last decade. The results were promising as collagen cross-linking showed significant improvement in visual acuity and keratometric values. Moreover, initial results show that it is a safe procedure with few reported complications.

Conclusion: CXL is an emerging treatment method in ophthalmology that offers the possibility to effectively treat progressive KCN.

Citing Articles

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The impact of interrupted corneal collagen crosslinking (CXL) treatment.

Tholvsen M, Makdoumi K Graefes Arch Clin Exp Ophthalmol. 2024; 262(11):3643-3648.

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Prevalence of Keratoconus in the Young Eastern Population of Saudi Arabia.

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Intraocular pressure after combined photorefractive keratectomy and corneal collagen cross-linking for keratoconus.

Nabil K, Elmassry A, Ntakarusho S, Said A Int Ophthalmol. 2023; 43(12):4837-4849.

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The Underlying Relationship between Keratoconus and Down Syndrome.

Akoto T, Li J, Estes A, Karamichos D, Liu Y Int J Mol Sci. 2022; 23(18).

PMID: 36142709 PMC: 9503764. DOI: 10.3390/ijms231810796.

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