Accelerated Versus Conventional Corneal Collagen Cross-linking in Patients with Keratoconus: an Intrapatient Comparative Study

Overview

Journal Int Ophthalmol

Specialty Ophthalmology

Date 2016 Dec 31

PMID 28035498

Citations 22

Authors

Mohammad Mehdi Sadoughi

Bahram Einollahi

Alireza Baradaran-Rafii

Danial Roshandel

Hamidreza Hasani

Mehrdad Nazeri

Affiliations

Soon will be listed here.

Abstract

Purpose: To compare the outcomes of the conventional and accelerated corneal collagen cross-linking (CXL) in patients with bilateral progressive keratoconus (KC).

Methods: Fifteen consecutive patients with bilateral progressive KC were enrolled. In each patient, the fellow eyes were randomly assigned to the conventional CXL (3 mW/cm for 30 min) or accelerated CXL (ACXL) (9 mW/cm for 10 min) groups. Manifest refraction; uncorrected and corrected distant visual acuity; maximum and mean keratometry; corneal hysteresis and corneal resistance factor; endothelial cell density and morphology; central corneal thickness; and wavefront aberrations were measured before and 12 months after the CXL.

Results: Manifest refraction spherical equivalent and refractive cylinder improved significantly only in conventional group. Uncorrected and corrected distant visual acuity did not change significantly in either group. Also there was no significant change in the maximum and mean keratometry after 12 months. There was significant decrease in central corneal thickness in both groups which was more prominent in conventional group. Endothelial cell density reduced only in the conventional group which was not statistically significant (P = 0.147). CH, CRF, and wavefront aberrations did not change significantly in either group. We did not observe any significant difference in the changes of the variables between the two groups.

Conclusions: Accelerated CXL with 9 mW/cm irradiation for 10 min had similar refractive, visual, keratometric, and aberrometric results and less adverse effects on the corneal thickness and endothelial cells as compared with the conventional method after 12 months follow-up. However, randomized clinical trials with longer follow-ups and larger sample sizes are needed.

Citing Articles

Short- and long-term safety and efficacy of corneal collagen cross-linking in progressive keratoconus: A systematic review and meta-analysis of randomized controlled trials.

Sarma P, Kaur H, Hafezi F, Bhattacharyya J, Kirubakaran R, Prajapat M Taiwan J Ophthalmol. 2023; 13(2):191-202.

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Comparison of standard versus accelerated corneal collagen cross-linking for keratoconus: 5-year outcomes from the Save Sight Keratoconus Registry.

Kandel H, Abbondanza M, Gupta A, Mills R, Watson A, Petsoglou C Eye (Lond). 2023; 38(1):95-102.

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Determination of efficacy of repeated CXL and probable risk factors in patients with progressive keratoconus.

Jamali H, Bagheri M, Khalili M Int Ophthalmol. 2023; 43(9):3157-3164.

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Network meta-analysis comparing efficacy and safety of different protocols of corneal cross-linking for the treatment of progressive keratoconus.

Ding L, Sun L, Zhou X Graefes Arch Clin Exp Ophthalmol. 2023; 261(10):2743-2753.

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One-year non-comparative observational study to evaluate corneal tomographic, densitometric, and aberrometric features following accelerated corneal cross-linking in progressive keratoconus.

Mohebbi M, Samavat B, Mohammadi A Int Ophthalmol. 2022; 43(5):1721-1735.

PMID: 36418804 DOI: 10.1007/s10792-022-02572-3.

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