Studies of LncRNAs in DNA Double Strand Break Repair: What is New?

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Dec 20

PMID 29254281

Citations 6

Authors

Zhenzhen Wu

Yuming Wang

Affiliations

Soon will be listed here.

Abstract

The 'junk DNA' that has haunted human genetics for a long time now turns out to hold enormous hidden treasures. As species had their genomes and transcriptomes sequenced, there are an overwhelming number of lncRNA transcripts being reported, however, less than 100 of them have been functionally characterized. DNA damage is recognized and quickly repaired by the cell, with increased expression of numerous genes involved in DNA repair. Most of the time the studies have focused only on proteins involved in these signaling pathways. However, recent studies have implied that lncRNAs can be broadly induced by DNA damage and regulate DNA repair processes by various mechanisms. In this paper, we focus on recent advances in the identification and functional characterization of novel lncRNAs participating in DNA double strand break repair.

Citing Articles

Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance in Cancer Cells.

Jalali-Zefrei F, Mousavi S, Delpasand K, Shourmij M, Farzipour S Curr Gene Ther. 2024; 25(2):113-135.

PMID: 38676526 DOI: 10.2174/0115665232301727240422092311.

lincRNA-RP11400K9.4 Regulates Cell Survival and Migration of Breast Cancer Cells.

Fernandez-Rojas M, Melendez-Zajgla J, Maldonado Lagunas V Cancer Genomics Proteomics. 2020; 17(6):769-779.

PMID: 33099478 PMC: 7675660. DOI: 10.21873/cgp.20231.

Characterization of BRCA1/2-Directed ceRNA Network Identifies a Novel Three-lncRNA Signature to Predict Prognosis and Chemo-Response in Ovarian Cancer Patients With Wild-Type BRCA1/2.

Zhang M, Wang G, Zhu Y, Wu D Front Cell Dev Biol. 2020; 8:680.

PMID: 32850807 PMC: 7403448. DOI: 10.3389/fcell.2020.00680.

Deciphering the Mounting Complexity of the p53 Regulatory Network in Correlation to Long Non-Coding RNAs (lncRNAs) in Ovarian Cancer.

Pal S, Garg M, Pandey A Cells. 2020; 9(3).

PMID: 32106407 PMC: 7140525. DOI: 10.3390/cells9030527.

The Role of Noncoding RNAs in Double-Strand Break Repair.

Durut N, Mittelsten Scheid O Front Plant Sci. 2019; 10:1155.

PMID: 31611891 PMC: 6776598. DOI: 10.3389/fpls.2019.01155.

References

Gao J, Zhang H, Arbman G, Sun X . RAD50/MRE11/NBS1 proteins in relation to tumour development and prognosis in patients with microsatellite stable colorectal cancer. Histol Histopathol. 2008; 23(12):1495-502. DOI: 10.14670/HH-23.1495. View

Ziolkowska-Suchanek I, Mosor M, Wierzbicka M, Rydzanicz M, Baranowska M, Nowak J . The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers. Mol Cancer. 2013; 12(1):113. PMC: 3856607. DOI: 10.1186/1476-4598-12-113. View

Finkbeiner M, Astanehe A, To K, Fotovati A, Davies A, Zhao Y . Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells. Oncogene. 2009; 28(11):1421-31. DOI: 10.1038/onc.2008.485. View

Halazonetis T, Gorgoulis V, Bartek J . An oncogene-induced DNA damage model for cancer development. Science. 2008; 319(5868):1352-5. DOI: 10.1126/science.1140735. View

Wood R, Doublie S . DNA polymerase θ (POLQ), double-strand break repair, and cancer. DNA Repair (Amst). 2016; 44:22-32. PMC: 5114520. DOI: 10.1016/j.dnarep.2016.05.003. View

Moynahan M, Jasin M . Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol. 2010; 11(3):196-207. PMC: 3261768. DOI: 10.1038/nrm2851. View

Feuerhahn S, Egly J . Tools to study DNA repair: what's in the box?. Trends Genet. 2008; 24(9):467-74. DOI: 10.1016/j.tig.2008.07.003. View

Chen H, Lisby M, Symington L . RPA coordinates DNA end resection and prevents formation of DNA hairpins. Mol Cell. 2013; 50(4):589-600. PMC: 3855855. DOI: 10.1016/j.molcel.2013.04.032. View

Cheetham S, Gruhl F, Mattick J, Dinger M . Long noncoding RNAs and the genetics of cancer. Br J Cancer. 2013; 108(12):2419-25. PMC: 3694235. DOI: 10.1038/bjc.2013.233. View

10.

Kornienko A, Guenzl P, Barlow D, Pauler F . Gene regulation by the act of long non-coding RNA transcription. BMC Biol. 2013; 11:59. PMC: 3668284. DOI: 10.1186/1741-7007-11-59. View

11.

Clemson C, Hutchinson J, Sara S, Ensminger A, Fox A, Chess A . An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Mol Cell. 2009; 33(6):717-26. PMC: 2696186. DOI: 10.1016/j.molcel.2009.01.026. View

12.

Kowalski M, Przybylowska K, Rusin P, Olszewski J, Morawiec-Sztandera A, Bielecka-Kowalska A . Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck. J Exp Clin Cancer Res. 2009; 28:37. PMC: 2660298. DOI: 10.1186/1756-9966-28-37. View

13.

Schaue D, McBride W . Opportunities and challenges of radiotherapy for treating cancer. Nat Rev Clin Oncol. 2015; 12(9):527-40. PMC: 8396062. DOI: 10.1038/nrclinonc.2015.120. View

14.

Broustas C, Lieberman H . DNA damage response genes and the development of cancer metastasis. Radiat Res. 2014; 181(2):111-30. PMC: 4064942. DOI: 10.1667/RR13515.1. View

15.

Krug L, Wozniak A, Kindler H, Feld R, Koczywas M, Morero J . Randomized phase II trial of pemetrexed/cisplatin with or without CBP501 in patients with advanced malignant pleural mesothelioma. Lung Cancer. 2014; 85(3):429-34. DOI: 10.1016/j.lungcan.2014.06.008. View

16.

Norquist B, Wurz K, Pennil C, Garcia R, Gross J, Sakai W . Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. J Clin Oncol. 2011; 29(22):3008-15. PMC: 3157963. DOI: 10.1200/JCO.2010.34.2980. View

17.

Bernstein N, Williams R, Rakovszky M, Cui D, Green R, Karimi-Busheri F . The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. Mol Cell. 2005; 17(5):657-70. DOI: 10.1016/j.molcel.2005.02.012. View

18.

Rybicki B, Conti D, Moreira A, Cicek M, Casey G, Witte J . DNA repair gene XRCC1 and XPD polymorphisms and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2004; 13(1):23-9. DOI: 10.1158/1055-9965.epi-03-0053. View

19.

Ulitsky I, Bartel D . lincRNAs: genomics, evolution, and mechanisms. Cell. 2013; 154(1):26-46. PMC: 3924787. DOI: 10.1016/j.cell.2013.06.020. View

20.

Pylkas K, Vuorela M, Otsukka M, Kallioniemi A, Jukkola-Vuorinen A, Winqvist R . Rare copy number variants observed in hereditary breast cancer cases disrupt genes in estrogen signaling and TP53 tumor suppression network. PLoS Genet. 2012; 8(6):e1002734. PMC: 3380845. DOI: 10.1371/journal.pgen.1002734. View