Chaperone-mediated Autophagy and Endosomal Microautophagy: Joint by a Chaperone

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2017 Dec 17

PMID 29247007

Citations 166

Authors

Kumsal Tekirdag

Ana Maria Cuervo

Affiliations

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Abstract

A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for degradation through autophagy. Here, we focus on two autophagic pathways, the chaperone-mediated autophagy and the endosomal microautophagy that rely on the cytosolic chaperone hsc70 for substrate targeting. Although hsc70 participates in the triage of proteins for degradation by different proteolytic systems, the common characteristic shared by these two forms of autophagy is that hsc70 binds directly to a specific five-amino acid motif in the cargo protein for its autophagic targeting. We summarize the current understanding of the molecular machineries behind each of these types of autophagy.

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