Pituitary Adenomas, Stem Cells, and Cancer Stem Cells: What's New?

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 2017 Dec 10

PMID 29222642

Citations 10

Authors

M Caffarini

M Orciani

L Trementino

R Di Primio

G Arnaldi

Affiliations

Soon will be listed here.

Abstract

Purpose: To clarify the existence of pituitary stem cells (SCs) both in the embryonic and the postnatal gland and the role for SCs in pituitary adenomas.

Methods: This work, which does not address the pathogenesis of pituitary adenomas, reviews the latest research findings and discoveries on SCs in pituitary and cancer SCs (CSCs) in pituitary adenomas and discusses the involvement of the EMT.

Results: Several groups using different approaches and techniques have demonstrated the existence of SCs and CSCs and as they are major players in pituitary adenoma onset.

Conclusions: As in other benign and malignant tumors, the hypothesis that CSCs play a pivotal role in pituitary adenoma onset has been confirmed as well as the existence of a link between the epithelial-to-mesenchymal transition (EMT) process and CSC formation in epithelial tumors.

Citing Articles

Role of Tumor Microenvironment in Pituitary Neuroendocrine Tumors: New Approaches in Classification, Diagnosis and Therapy.

Tapoi D, Popa M, Tanase C, Derewicz D, Gheorghisan-Galateanu A Cancers (Basel). 2023; 15(21).

PMID: 37958474 PMC: 10649263. DOI: 10.3390/cancers15215301.

Distribution, contribution and regulation of nestin cells.

Tong Z, Yin Z J Adv Res. 2023; 61:47-63.

PMID: 37648021 PMC: 11258671. DOI: 10.1016/j.jare.2023.08.013.

Architects of Pituitary Tumour Growth.

Sabatino M, Grondona E, De Paul A Front Endocrinol (Lausanne). 2022; 13:924942.

PMID: 35837315 PMC: 9273718. DOI: 10.3389/fendo.2022.924942.

Clinical Biology of the Pituitary Adenoma.

Melmed S, Kaiser U, Lopes M, Bertherat J, Syro L, Raverot G Endocr Rev. 2022; 43(6):1003-1037.

PMID: 35395078 PMC: 9695123. DOI: 10.1210/endrev/bnac010.

Up-regulation of sex-determining region Y-box 9 (SOX9) in growth hormone-secreting pituitary adenomas.

Shirian F, Ghorbani M, Khamseh M, Imani M, Panahi M, Alimohammadi A BMC Endocr Disord. 2021; 21(1):50.

PMID: 33736633 PMC: 7971953. DOI: 10.1186/s12902-021-00720-x.

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