Effect of Sleep on Overnight Cerebrospinal Fluid Amyloid β Kinetics

Overview

Journal Ann Neurol

Specialty Neurology

Date 2017 Dec 9

PMID 29220873

Citations 152

Authors

Brendan P Lucey

Terry J Hicks

Jennifer S McLeland

Cristina D Toedebusch

Jill Boyd

Donald L Elbert

Bruce W Patterson

Jack Baty

John C Morris

Vitaliy Ovod

Kwasi G Mawuenyega

Randall J Bateman

Affiliations

Soon will be listed here.

Abstract

Sleep disturbances are associated with future risk of Alzheimer disease. Disrupted sleep increases soluble amyloid β, suggesting a mechanism for sleep disturbances to increase Alzheimer disease risk. We tested this response in humans using indwelling lumbar catheters to serially sample cerebrospinal fluid while participants were sleep-deprived, treated with sodium oxybate, or allowed to sleep normally. All participants were infused with C -leucine to measure amyloid β kinetics. We found that sleep deprivation increased overnight amyloid β38, amyloid β40, and amyloid β42 levels by 25 to 30% via increased overnight amyloid β production relative to sleeping controls. These findings suggest that disrupted sleep increases Alzheimer disease risk via increased amyloid β production. Ann Neurol 2018;83:197-204.

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