Waste Clearance Shapes Aging Brain Health

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2024 Oct 12

PMID 39395409

Authors

Li-Feng Jiang-Xie

Antoine Drieu

Jonathan Kipnis

Affiliations

Soon will be listed here.

Abstract

Brain health is intimately connected to fluid flow dynamics that cleanse the brain of potentially harmful waste material. This system is regulated by vascular dynamics, the maintenance of perivascular spaces, neural activity during sleep, and lymphatic drainage in the meningeal layers. However, aging can impinge on each of these layers of regulation, leading to impaired brain cleansing and the emergence of various age-associated neurological disorders, including Alzheimer's and Parkinson's diseases. Understanding the intricacies of fluid flow regulation in the brain and how this becomes altered with age could reveal new targets and therapeutic strategies to tackle age-associated neurological decline.

Citing Articles

Perivascular and parenchymal fluid characteristics are related to age and cognitive performance across the lifespan.

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