Research on HIV Cure: Mapping the Ethics Landscape

Overview

Journal PLoS Med

Specialty General Medicine

Date 2017 Dec 9

PMID 29220353

Citations 19

Authors

Karine Dube

Laurie Sylla

Lynda Dee

Jeff Taylor

David Evans

Carl Dean Bruton

Adam Gilberston

Lisa Gralinski

Brandon Brown

Asheley Skinner

Bryan J Weiner

Sandra B Greene

Amy Corneli

Adaora A Adimora

Joseph D Tucker

Stuart Rennie

Affiliations

Soon will be listed here.

Abstract

In an essay, Karine Dubé and coauthors discuss the ethics of preclinical and clinical studies relevant to achieving an HIV cure.

Citing Articles

'With this study, we have hope that something is coming': community members' perceptions of HIV cure-related research in Durban, South Africa - a qualitative focus group study.

Dube K, Mthimkhulu D, Ngcobo W, Mindry D, Maphalala L, Pillay V HIV Res Clin Pract. 2023; 24(1):2243046.

PMID: 37555592 PMC: 10433450.

Community engagement group model in basic and biomedical research: lessons learned from the BEAT-HIV Delaney Collaboratory towards an HIV-1 cure.

Dube K, Peterson B, Jones N, Onorato A, Carter W, Dannaway C Res Involv Engagem. 2023; 9(1):39.

PMID: 37291622 PMC: 10248979. DOI: 10.1186/s40900-023-00449-y.

Ethical and practical considerations for cell and gene therapy toward an HIV cure: findings from a qualitative in-depth interview study in the United States.

Dube K, Kanazawa J, Patel H, Louella M, Sylla L, Sheehy J BMC Med Ethics. 2022; 23(1):39.

PMID: 35397551 PMC: 8994300. DOI: 10.1186/s12910-022-00780-1.

The perceived impact of an HIV cure by people living with HIV and key populations vulnerable to HIV in the Netherlands: A qualitative study.

Romijnders K, de Groot L, Vervoort S, Basten M, van Welzen B, Kretzschmar M J Virus Erad. 2022; 8(1):100066.

PMID: 35280938 PMC: 8907669. DOI: 10.1016/j.jve.2022.100066.

Considerations for designing and implementing combination HIV cure trials: findings from a qualitative in-depth interview study in the United States.

Dube K, Kanazawa J, Dee L, Taylor J, Sauceda J, Gianella S AIDS Res Ther. 2021; 18(1):75.

PMID: 34663375 PMC: 8522863. DOI: 10.1186/s12981-021-00401-8.

References

Sugarman J, Lewin S, Henrich T, Rasmussen T . Ethics of ART interruption after stem-cell transplantation. Lancet HIV. 2016; 3(1):e8-10. DOI: 10.1016/S2352-3018(15)00248-9. View

Margolis D, Hazuda D . Combined approaches for HIV cure. Curr Opin HIV AIDS. 2013; 8(3):230-5. PMC: 3966301. DOI: 10.1097/COH.0b013e32835ef089. View

van der Worp H, Howells D, Sena E, Porritt M, Rewell S, OCollins V . Can animal models of disease reliably inform human studies?. PLoS Med. 2010; 7(3):e1000245. PMC: 2846855. DOI: 10.1371/journal.pmed.1000245. View

Dube K, Evans D, Dee L, Sylla L, Taylor J, Skinner A . "We Need to Deploy Them Very Thoughtfully and Carefully": Perceptions of Analytical Treatment Interruptions in HIV Cure Research in the United States-A Qualitative Inquiry. AIDS Res Hum Retroviruses. 2017; 34(1):67-79. PMC: 5771546. DOI: 10.1089/AID.2017.0067. View

Henderson G . The ethics of HIV "cure" research: what can we learn from consent forms?. AIDS Res Hum Retroviruses. 2014; 31(1):56-63. PMC: 4287120. DOI: 10.1089/AID.2014.0219. View

Sereti I, Folkers G, Meintjes G, Boulware D . Towards a scalable HIV cure research agenda: the role of co-infections. J Virus Erad. 2016; 1(4):269-271. PMC: 4739889. View

Brown B, Galea J, Davidson P, Khoshnood K . Transparency of participant incentives in HIV research. Lancet HIV. 2016; 3(10):e456-7. PMC: 5578702. DOI: 10.1016/S2352-3018(16)30150-3. View

Lederman M, Cannon P, Currier J, June C, Kiem H, Kuritzkes D . A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?. Pathog Immun. 2016; 1(1):154-164. PMC: 5033048. DOI: 10.20411/pai.v1i1.133. View

Lundgren J, Babiker A, Gordin F, Emery S, Grund B, Sharma S . Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection. N Engl J Med. 2015; 373(9):795-807. PMC: 4569751. DOI: 10.1056/NEJMoa1506816. View

10.

Kummar S, Rubinstein L, Kinders R, Parchment R, Gutierrez M, Murgo A . Phase 0 clinical trials: conceptions and misconceptions. Cancer J. 2008; 14(3):133-7. PMC: 7185299. DOI: 10.1097/PPO.0b013e318172d6f3. View

11.

Dube K, Taylor J, Sylla L, Evans D, Dee L, Burton A . 'Well, It's the Risk of the Unknown… Right?': A Qualitative Study of Perceived Risks and Benefits of HIV Cure Research in the United States. PLoS One. 2017; 12(1):e0170112. PMC: 5266311. DOI: 10.1371/journal.pone.0170112. View

12.

Nakagawa F, Lodwick R, Smith C, Smith R, Cambiano V, Lundgren J . Projected life expectancy of people with HIV according to timing of diagnosis. AIDS. 2011; 26(3):335-43. DOI: 10.1097/QAD.0b013e32834dcec9. View

13.

Allers K, Hutter G, Hofmann J, Loddenkemper C, Rieger K, Thiel E . Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood. 2010; 117(10):2791-9. DOI: 10.1182/blood-2010-09-309591. View

14.

Shah S . When to start paediatric testing of the adult HIV cure research agenda?. J Med Ethics. 2016; 43(2):82-86. PMC: 5293843. DOI: 10.1136/medethics-2015-103116. View

15.

Kagarise M, Sheldon G . Translational ethics: a perspective for the new millennium. Arch Surg. 2000; 135(1):39-45. DOI: 10.1001/archsurg.135.1.39. View

16.

Kuritzkes D . Why cure, why now?. J Med Ethics. 2016; 43(2):67-70. PMC: 5293855. DOI: 10.1136/medethics-2015-103113. View

17.

Lo B, Grady C . Ethical considerations in HIV cure research: points to consider. Curr Opin HIV AIDS. 2013; 8(3):243-9. PMC: 4825800. DOI: 10.1097/COH.0b013e32835ea1c5. View

18.

Shytaj I, Savarino A . A cure for AIDS: a matter of timing?. Retrovirology. 2013; 10:145. PMC: 3842794. DOI: 10.1186/1742-4690-10-145. View

19.

Kimmelman J, London A . Predicting harms and benefits in translational trials: ethics, evidence, and uncertainty. PLoS Med. 2011; 8(3):e1001010. PMC: 3050916. DOI: 10.1371/journal.pmed.1001010. View

20.

Dube K, Dee L, Evans D, Sylla L, Taylor J, Brown B . Perceptions of Equipoise, Risk-Benefit Ratios, and "Otherwise Healthy Volunteers" in the Context of Early-Phase HIV Cure Research in the United States: A Qualitative Inquiry. J Empir Res Hum Res Ethics. 2017; 13(1):3-17. PMC: 5768449. DOI: 10.1177/1556264617734061. View