Skiving Stacked Sheets of Paper into Test Paper for Rapid and Multiplexed Assay

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2017 Dec 8

PMID 29214218

Citations 15

Authors

Mingzhu Yang

Wei Zhang

Junchuan Yang

Binfeng Hu

Fengjing Cao

Wenshu Zheng

Yiping Chen

Xingyu Jiang

Affiliations

Soon will be listed here.

Abstract

This paper shows that stacked sheets of paper preincubated with different biological reagents and skiving them into uniform test paper sheets allow mass manufacturing of multiplexed immunoassay devices and simultaneous detection of multiplex targets that can be read out by a barcode scanner. The thickness of one sheet of paper can form the width of a module for the barcode; when stacked, these sheets of paper can form a series of barcodes representing the targets, depending on the color contrast provided by a colored precipitate of an immunoassay. The uniform thickness of sheets of paper allows high-quality signal readout. The manufacturing method allows highly efficient fabrication of the materials and substrates for a straightforward assay of targets that range from drugs of abuse to biomarkers of blood-transmitted infections. In addition, as a novel alternative to the conventional point-of-care testing method, the paper-based barcode assay system can provide highly efficient, accurate, and objective diagnoses.

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References

Qin Z, Chan W, Boulware D, Akkin T, Butler E, Bischof J . Significantly improved analytical sensitivity of lateral flow immunoassays by using thermal contrast. Angew Chem Int Ed Engl. 2012; 51(18):4358-61. PMC: 3337364. DOI: 10.1002/anie.201200997. View

Renault C, Anderson M, Crooks R . Electrochemistry in hollow-channel paper analytical devices. J Am Chem Soc. 2014; 136(12):4616-23. DOI: 10.1021/ja4118544. View

Zhang Y, Sun J, Zou Y, Chen W, Zhang W, Xi J . Barcoded microchips for biomolecular assays. Anal Chem. 2014; 87(2):900-6. DOI: 10.1021/ac5032379. View

Liu M, Hui C, Zhang Q, Gu J, Kannan B, Jahanshahi-Anbuhi S . Target-Induced and Equipment-Free DNA Amplification with a Simple Paper Device. Angew Chem Int Ed Engl. 2016; 55(8):2709-13. DOI: 10.1002/anie.201509389. View

Guan L, Tian J, Cao R, Li M, Cai Z, Shen W . Barcode-like paper sensor for smartphone diagnostics: an application of blood typing. Anal Chem. 2014; 86(22):11362-7. DOI: 10.1021/ac503300y. View

Cunningham J, Brenes N, Crooks R . Paper electrochemical device for detection of DNA and thrombin by target-induced conformational switching. Anal Chem. 2014; 86(12):6166-70. DOI: 10.1021/ac501438y. View

Chen J, Zhou S, Wen J . Disposable strip biosensor for visual detection of Hg(2+) based on Hg(2+)-triggered toehold binding and exonuclease III-assisted signal amplification. Anal Chem. 2014; 86(6):3108-14. DOI: 10.1021/ac404170j. View

Chen Y, Xianyu Y, Wang Y, Zhang X, Cha R, Sun J . One-step detection of pathogens and viruses: combining magnetic relaxation switching and magnetic separation. ACS Nano. 2015; 9(3):3184-91. DOI: 10.1021/acsnano.5b00240. View

Li M, Tian J, Al-Tamimi M, Shen W . Paper-based blood typing device that reports patient's blood type "in writing". Angew Chem Int Ed Engl. 2012; 51(22):5497-501. DOI: 10.1002/anie.201201822. View

10.

Xu Q, Rioux R, Whitesides G . Fabrication of complex metallic nanostructures by nanoskiving. ACS Nano. 2009; 1(3):215-27. DOI: 10.1021/nn700172c. View

11.

Sun J, Xianyu Y, Jiang X . Point-of-care biochemical assays using gold nanoparticle-implemented microfluidics. Chem Soc Rev. 2014; 43(17):6239-53. DOI: 10.1039/c4cs00125g. View

12.

Yu L, Shi Z . Microfluidic paper-based analytical devices fabricated by low-cost photolithography and embossing of Parafilm®. Lab Chip. 2015; 15(7):1642-5. DOI: 10.1039/c5lc00044k. View

13.

Fraikin J, Teesalu T, McKenney C, Ruoslahti E, Cleland A . A high-throughput label-free nanoparticle analyser. Nat Nanotechnol. 2011; 6(5):308-13. DOI: 10.1038/nnano.2011.24. View

14.

Xianyu Y, Wang Z, Jiang X . A plasmonic nanosensor for immunoassay via enzyme-triggered click chemistry. ACS Nano. 2014; 8(12):12741-7. DOI: 10.1021/nn505857g. View

15.

Badu-Tawiah A, Lathwal S, Kaastrup K, Al-Sayah M, Christodouleas D, Smith B . Polymerization-based signal amplification for paper-based immunoassays. Lab Chip. 2014; 15(3):655-9. DOI: 10.1039/c4lc01239a. View

16.

Wong J, Li X, Liu F, Yu H . Direct Reading of Bona Fide Barcode Assays for Diagnostics with Smartphone Apps. Sci Rep. 2015; 5:11727. PMC: 4485167. DOI: 10.1038/srep11727. View

17.

Zhang C, Johnson L . Single quantum-dot-based aptameric nanosensor for cocaine. Anal Chem. 2009; 81(8):3051-5. PMC: 2736799. DOI: 10.1021/ac802737b. View

18.

Parolo C, Merkoci A . Paper-based nanobiosensors for diagnostics. Chem Soc Rev. 2012; 42(2):450-7. DOI: 10.1039/c2cs35255a. View

19.

Zhu Z, Guan Z, Liu D, Jia S, Li J, Lei Z . Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis. Angew Chem Int Ed Engl. 2015; 54(36):10448-53. DOI: 10.1002/anie.201503963. View

20.

Xu Q, Bao J, Rioux R, Perez-Castillejos R, Capasso F, Whitesides G . Fabrication of large-area patterned nanostructures for optical applications by nanoskiving. Nano Lett. 2007; 7(9):2800-5. DOI: 10.1021/nl0713979. View