Gastrointestinal Symptoms and Elevated Levels of Anti- Antibodies Are Associated with Higher Disease Activity in Colombian Patients with Spondyloarthritis

Overview

Journal Int J Rheumatol

Publisher Wiley

Specialty Rheumatology

Date 2017 Dec 8

PMID 29213287

Citations 7

Authors

C Romero-Sanchez

W Bautista-Molano

V Parra

J De Avila

J C Rueda

J M Bello-Gualtero

J Londono

R Valle-Onate

Affiliations

Soon will be listed here.

Abstract

Background: Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status.

Objectives: To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and patients with inflammatory bowel disease (IBD).

Methods: 102 SpA patients, 29 IBD patients, and 117 HS were included. Autoantibodies as ASCA, ANCA, anti-tTG, anti-DGP, ANA, and IgA were measured. The patients were assessed to evaluate clinical and gastrointestinal symptoms. An association analysis was performed using Chi square test and a logistic regression.

Results: Significant differences were found for ASCA levels in SpA (28.2%) compared to IBD (14.2%) and HS (6.0%) ( = 0.029), as well as for ANAS in SpA (49.5%) and IBD (37.9%) ( < 0.001) and abdominal pain ( = 0.012) between SpA (54.3%) and IBD (27.5%). Significant associations were found between BASDAI > 4 and gastrointestinal symptoms ( < 0.05) and IgA ( = 0.007). The association for abdominal bloating was maintained (OR: 3.93, CI-95%, 1.14-13.56; = 0.030).

Conclusions: Gastrointestinal symptoms, ASCA, ANAS, and IgA levels were associated with high disease activity in SpA compared with IBD and HS.

Citing Articles

Impact of gastrointestinal and psychological symptoms on disease activity and functional impairment in patients with spondyloarthritis: a cross-sectional study.

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Elevated Calprotectin Levels Reveal Loss of Vascular Pattern and Atrophy of Villi in Ileum by Digital Chromoendoscopy and Magnification Colonoscopy in Patients with Spondyloarthritis Without Having Inflammatory Bowel Disease.

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Colonoscopy aspiration lavages for mucosal metataxonomic profiling of spondylarthritis-associated gastrointestinal tract alterations.

Marquez-Ortiz R, Leon M, Abril D, Escobar-Perez J, Florez-Sarmiento C, Parra-Izquierdo V Sci Rep. 2023; 13(1):7015.

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Oral manifestations associated with inflammatory bowel disease and early endoscopic findings in patients with spondyloarthritis.

Alvarado-Julio A, Chumacero-Palma K, Buenahora M, Parra-Izquierdo V, Monsalve M, Torres A BMC Oral Health. 2022; 22(1):477.

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