Is Genetic Mobilization Considered When Using Bacteriophages in Antimicrobial Therapy?

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2017 Dec 6

PMID 29206153

Citations 7

Authors

Lorena Rodriguez-Rubio

Joan Jofre

Maite Muniesa

Affiliations

Soon will be listed here.

Abstract

The emergence of multi-drug resistant bacteria has undermined our capacity to control bacterial infectious diseases. Measures needed to tackle this problem include controlling the spread of antibiotic resistance, designing new antibiotics, and encouraging the use of alternative therapies. Phage therapy seems to be a feasible alternative to antibiotics, although there are still some concerns and legal issues to overcome before it can be implemented on a large scale. Here we highlight some of those concerns, especially those related to the ability of bacteriophages to transport bacterial DNA and, in particular, antibiotic resistance genes.

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