Developmental HSC Microenvironments: Lessons from Zebrafish

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2017 Dec 6

PMID 29204828

Citations 8

Authors

Sara Nik

Joshua T Weinreb

Teresa V Bowman

Affiliations

Soon will be listed here.

Abstract

Hematopoietic stem cells (HSCs) posses the ability to maintain the blood system of an organism from birth to adulthood. The behavior of HSCs is modulated by its microenvironment. During development, HSCs acquire the instructions to self-renew and differentiate into all blood cell fates by passing through several developmental microenvironments. In this chapter, we discuss the signals and cell types that inform HSC decisions throughout ontogeny with a focus on HSC specification, mobilization, migration, and engraftment.

Citing Articles

Inflammation in Development and Aging: Insights from the Zebrafish Model.

Mastrogiovanni M, Martinez-Navarro F, Bowman T, Cayuela M Int J Mol Sci. 2024; 25(4).

PMID: 38396822 PMC: 10889087. DOI: 10.3390/ijms25042145.

Learning from Zebrafish Hematopoiesis.

Wu M, Xu J, Zhang Y, Wen Z Adv Exp Med Biol. 2024; 1442:137-157.

PMID: 38228963 DOI: 10.1007/978-981-99-7471-9_9.

Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition.

Potts K, Cameron R, Metidji A, Ghazale N, Wallace L, Leal-Cervantes A Cell Rep. 2022; 41(11):111825.

PMID: 36516770 PMC: 9994853. DOI: 10.1016/j.celrep.2022.111825.

Dhx15 regulates zebrafish definitive hematopoiesis through the unfolded protein response pathway.

Cai Y, Wang J, Jin D, Liu Q, Chen X, Pan L Cancer Sci. 2021; 112(9):3884-3894.

PMID: 34077586 PMC: 8409414. DOI: 10.1111/cas.15002.

Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production.

Weinreb J, Ghazale N, Pradhan K, Gupta V, Potts K, Tricomi B Dev Cell. 2021; 56(5):627-640.e5.

PMID: 33651979 PMC: 8258699. DOI: 10.1016/j.devcel.2021.02.006.

References

Crane G, Jeffery E, Morrison S . Adult haematopoietic stem cell niches. Nat Rev Immunol. 2017; 17(9):573-590. DOI: 10.1038/nri.2017.53. View

North T, Goessling W, Peeters M, Li P, Ceol C, Lord A . Hematopoietic stem cell development is dependent on blood flow. Cell. 2009; 137(4):736-48. PMC: 2722870. DOI: 10.1016/j.cell.2009.04.023. View

Espin-Palazon R, Stachura D, Campbell C, Garcia-Moreno D, Del Cid N, Kim A . Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 2014; 159(5):1070-1085. PMC: 4243083. DOI: 10.1016/j.cell.2014.10.031. View

Murayama E, Sarris M, Redd M, Le Guyader D, Vivier C, Horsley W . NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation. Nat Commun. 2015; 6:8375. DOI: 10.1038/ncomms9375. View

Kirstein-Miles J, Scior A, Deuerling E, Morimoto R . The nascent polypeptide-associated complex is a key regulator of proteostasis. EMBO J. 2013; 32(10):1451-68. PMC: 3655472. DOI: 10.1038/emboj.2013.87. View

Carroll K, Esain V, Garnaas M, Cortes M, Dovey M, Nissim S . Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Dev Cell. 2014; 29(4):437-53. PMC: 4469361. DOI: 10.1016/j.devcel.2014.04.012. View

Medvinsky A, Dzierzak E . Definitive hematopoiesis is autonomously initiated by the AGM region. Cell. 1996; 86(6):897-906. DOI: 10.1016/s0092-8674(00)80165-8. View

Holderfield M, Hughes C . Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ Res. 2008; 102(6):637-52. DOI: 10.1161/CIRCRESAHA.107.167171. View

Adamo L, Naveiras O, Wenzel P, McKinney-Freeman S, Mack P, Gracia-Sancho J . Biomechanical forces promote embryonic haematopoiesis. Nature. 2009; 459(7250):1131-5. PMC: 2782763. DOI: 10.1038/nature08073. View

10.

Espin R, Roca F, Candel S, Sepulcre M, Gonzalez-Rosa J, Alcaraz-Perez F . TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Dis Model Mech. 2012; 6(2):383-96. PMC: 3597020. DOI: 10.1242/dmm.010249. View

11.

Pierce H, Zhang D, Magnon C, Lucas D, Christin J, Huggins M . Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay. Cell Stem Cell. 2017; 20(5):648-658.e4. PMC: 5467872. DOI: 10.1016/j.stem.2017.01.002. View

12.

Lee J, Yu Q, Shin J, Sebzda E, Bertozzi C, Chen M . Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell. 2006; 11(6):845-57. DOI: 10.1016/j.devcel.2006.09.006. View

13.

Lim S, Esain V, Kwan W, Theodore L, Cortes M, Frost I . HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Exp Hematol. 2016; 46:83-95.e6. PMC: 5338611. DOI: 10.1016/j.exphem.2016.10.002. View

14.

Habeck H, Odenthal J, Walderich B, Maischein H, Schulte-Merker S . Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis. Curr Biol. 2002; 12(16):1405-12. DOI: 10.1016/s0960-9822(02)01044-8. View

15.

Baldridge M, King K, Boles N, Weksberg D, Goodell M . Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature. 2010; 465(7299):793-7. PMC: 2935898. DOI: 10.1038/nature09135. View

16.

Essers M, Offner S, Blanco-Bose W, Waibler Z, Kalinke U, Duchosal M . IFNalpha activates dormant haematopoietic stem cells in vivo. Nature. 2009; 458(7240):904-8. DOI: 10.1038/nature07815. View

17.

Sawamiphak S, Kontarakis Z, Stainier D . Interferon gamma signaling positively regulates hematopoietic stem cell emergence. Dev Cell. 2014; 31(5):640-53. PMC: 4371141. DOI: 10.1016/j.devcel.2014.11.007. View

18.

Feng C, Weksberg D, Taylor G, Sher A, Goodell M . The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell. 2008; 2(1):83-9. PMC: 2278017. DOI: 10.1016/j.stem.2007.10.007. View

19.

Tulchinsky D, Hobel C, YEAGER E, Marshall J . Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy. Am J Obstet Gynecol. 1972; 112(8):1095-100. DOI: 10.1016/0002-9378(72)90185-8. View

20.

Kobayashi I, Kobayashi-Sun J, Kim A, Pouget C, Fujita N, Suda T . Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling. Nature. 2014; 512(7514):319-23. PMC: 4237229. DOI: 10.1038/nature13623. View