Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm As an Emerging Inflammatory Disease

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2017 Dec 6

PMID 29203969

Citations 42

Authors

Calogera Pisano

Carmela Rita Balistreri

Alessandro Ricasoli

Giovanni Ruvolo

Affiliations

Soon will be listed here.

Abstract

Medial degeneration associated with thoracic aortic aneurysm and acute aortic dissection was originally described by Erdheim as a noninflammatory lesion related to the loss of smooth muscle cells and elastic fibre fragmentation in the media. Recent evidences propose the strong role of a chronic immune/inflammatory process in aneurysm evocation and progression. The coexistence of inflammatory cells with markers of apoptotic vascular cell death in the media of ascending aorta with aneurysms and type A dissections raises the possibility that activated T cells and macrophages may contribute to the elimination of smooth muscle cells and degradation of the matrix. On the other hand, several inflammatory pathways (including TGF-, TLR-4 interferon-, chemokines, and interferon-) seem to be involved in the medial degeneration related to aged and dilated aorta. This is an overview on thoracic aortic aneurysm as an emerging inflammatory disease.

Citing Articles

Mechanisms of aortic dissection: From pathological changes to experimental and models.

Rolf-Pissarczyk M, Schussnig R, Fries T, Fleischmann D, Elefteriades J, Humphrey J Prog Mater Sci. 2025; 150.

PMID: 39830801 PMC: 11737592. DOI: 10.1016/j.pmatsci.2024.101363.

Association Between Lipoprotein(a) and Dilatation of Different Aortic Segments in Hypertensive Patients.

Wang L, Ma C, Liu X, Han W Echocardiography. 2024; 42(1):e70061.

PMID: 39739981 PMC: 11683859. DOI: 10.1111/echo.70061.

Transcriptional regulation of postnatal aortic development.

Weiss D, Yeung N, Ramachandra A, Humphrey J Cells Dev. 2024; 180:203971.

PMID: 39426523 PMC: 11634634. DOI: 10.1016/j.cdev.2024.203971.

Macrophage in Sporadic Thoracic Aortic Aneurysm and Dissection: Potential Therapeutic and Preventing Target.

Song W, Tu G, Qin L, Wei L, Chen J Rev Cardiovasc Med. 2024; 24(12):340.

PMID: 39077089 PMC: 11272886. DOI: 10.31083/j.rcm2412340.

The key role of miRNA in syndromic and sporadic forms of ascending aortic aneurysms as biomarkers and targets of novel therapeutic strategies.

Terriaca S, Monastero R, Orlandi A, Balistreri C Front Genet. 2024; 15:1365711.

PMID: 38450200 PMC: 10915088. DOI: 10.3389/fgene.2024.1365711.

References

Ju X, Ijaz T, Sun H, LeJeune W, Vargas G, Shilagard T . IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR/mgR mouse model of severe Marfan syndrome. J Am Heart Assoc. 2014; 3(1):e000476. PMC: 3959679. DOI: 10.1161/JAHA.113.000476. View

Lindsay M, Schepers D, Bolar N, Doyle J, Gallo E, Fert-Bober J . Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm. Nat Genet. 2012; 44(8):922-7. PMC: 3616632. DOI: 10.1038/ng.2349. View

Katz A, Rolett E . Heart failure: when form fails to follow function. Eur Heart J. 2015; 37(5):449-54. DOI: 10.1093/eurheartj/ehv548. View

Nagaoka K, Sadamatsu K, Yamawaki T, Shikada T, Sagara S, Ohe K . Fibrinogen/fibrin degradation products in acute aortic dissection. Intern Med. 2010; 49(18):1943-7. DOI: 10.2169/internalmedicine.49.3770. View

Bachschmid M, Schildknecht S, Matsui R, Zee R, Haeussler D, Cohen R . Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Ann Med. 2012; 45(1):17-36. PMC: 3717565. DOI: 10.3109/07853890.2011.645498. View

Balistreri C, Maresi E, Pisano C, Di Maggio F, Vaccarino L, Caruso C . Identification of three particular morphological phenotypes in sporadic thoracic aortic aneurysm: phenotype III as sporadic thoracic aortic aneurysm biomarker in aged individuals. Rejuvenation Res. 2013; 17(2):192-6. DOI: 10.1089/rej.2013.1505. View

Pisano C, Balistreri C, Triolo O, Argano V, Ruvolo G . Acute Type A Aortic Dissection: Beyond the Diameter. J Heart Valve Dis. 2017; 25(6):764-768. View

Keller K, Howlett S . Sex Differences in the Biology and Pathology of the Aging Heart. Can J Cardiol. 2016; 32(9):1065-73. DOI: 10.1016/j.cjca.2016.03.017. View

Ruvolo G, Pisano C, Candore G, Lio D, Palmeri C, Maresi E . Can the TLR-4-mediated signaling pathway be "a key inflammatory promoter for sporadic TAA"?. Mediators Inflamm. 2014; 2014:349476. PMC: 4120489. DOI: 10.1155/2014/349476. View

10.

Akhurst R . The paradoxical TGF-β vasculopathies. Nat Genet. 2012; 44(8):838-9. PMC: 3543110. DOI: 10.1038/ng.2366. View

11.

Wang M, Monticone R, Lakatta E . Arterial aging: a journey into subclinical arterial disease. Curr Opin Nephrol Hypertens. 2009; 19(2):201-7. PMC: 2943205. DOI: 10.1097/MNH.0b013e3283361c0b. View

12.

Hazui H, Nishimoto M, Hoshiga M, Negoro N, Muraoka H, Murai M . Young adult patients with short dissection length and thrombosed false lumen without ulcer-like projections are liable to have false-negative results of D-dimer testing for acute aortic dissection based on a study of 113 cases. Circ J. 2006; 70(12):1598-601. DOI: 10.1253/circj.70.1598. View

13.

Yamada H, Sakata N, Wada H, Tashiro T, Tayama E . Age-related distensibility and histology of the ascending aorta in elderly patients with acute aortic dissection. J Biomech. 2015; 48(12):3267-73. DOI: 10.1016/j.jbiomech.2015.06.025. View

14.

Tieu B, Lee C, Sun H, LeJeune W, Recinos 3rd A, Ju X . An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J Clin Invest. 2009; 119(12):3637-51. PMC: 2786788. DOI: 10.1172/JCI38308. View

15.

Schillinger M, Domanovits H, Bayegan K, Holzenbein T, Grabenwoger M, Thoenissen J . C-reactive protein and mortality in patients with acute aortic disease. Intensive Care Med. 2002; 28(6):740-5. DOI: 10.1007/s00134-002-1299-1. View

16.

Jo Y, Anzai T, Ueno K, Kaneko H, Kohno T, Sugano Y . Re-elevation of D-dimer as a predictor of re-dissection and venous thromboembolism after Stanford type B acute aortic dissection. Heart Vessels. 2010; 25(6):509-14. DOI: 10.1007/s00380-010-0028-x. View

17.

Kumar H, Kawai T, Akira S . Toll-like receptors and innate immunity. Biochem Biophys Res Commun. 2009; 388(4):621-5. DOI: 10.1016/j.bbrc.2009.08.062. View

18.

Wen D, Wu H, Jiang X, Zhang H, Zhou X, Li J . Role of plasma C-reactive protein and white blood cell count in predicting in-hospital clinical events of acute type A aortic dissection. Chin Med J (Engl). 2011; 124(17):2678-82. View

19.

Lam C, Rienstra M, Tay W, Liu L, Hummel Y, van der Meer P . Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Association With Exercise Capacity, Left Ventricular Filling Pressures, Natriuretic Peptides, and Left Atrial Volume. JACC Heart Fail. 2016; 5(2):92-98. DOI: 10.1016/j.jchf.2016.10.005. View

20.

Satoh K, Nigro P, Berk B . Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A. Antioxid Redox Signal. 2009; 12(5):675-82. PMC: 2861539. DOI: 10.1089/ars.2009.2875. View