Magnetic Hydroxyapatite: a Promising Multifunctional Platform for Nanomedicine Application

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2017 Dec 5

PMID 29200851

Citations 20

Authors

Sudip Mondal

Panchanathan Manivasagan

Subramaniyan Bharathiraja

Madhappan Santha Moorthy

Hye Hyun Kim

Hansu Seo

Kang Dae Lee

Junghwan Oh

Affiliations

Soon will be listed here.

Abstract

In this review, specific attention is paid to the development of nanostructured magnetic hydroxyapatite (MHAp) and its potential application in controlled drug/gene delivery, tissue engineering, magnetic hyperthermia treatment, and the development of contrast agents for magnetic resonance imaging. Both magnetite and hydroxyapatite materials have excellent prospects in nanomedicine with multifunctional therapeutic approaches. To date, many research articles have focused on biomedical applications of nanomaterials because of which it is very difficult to focus on any particular type of nanomaterial. This study is possibly the first effort to emphasize on the comprehensive assessment of MHAp nanostructures for biomedical applications supported with very recent experimental studies. From basic concepts to the real-life applications, the relevant characteristics of magnetic biomaterials are patented which are briefly discussed. The potential therapeutic and diagnostic ability of MHAp-nanostructured materials make them an ideal platform for future nanomedicine. We hope that this advanced review will provide a better understanding of MHAp and its important features to utilize it as a promising material for multifunctional biomedical applications.

Citing Articles

Application of Nanohydroxyapatite in Medicine-A Narrative Review.

Lubojanski A, Zakrzewski W, Samol K, Bieszczad-Czaja M, Switala M, Wiglusz R Molecules. 2024; 29(23.

PMID: 39683785 PMC: 11643452. DOI: 10.3390/molecules29235628.

Evaluation of magnetic hyperthermia, drug delivery and biocompatibility (bone cell adhesion and zebrafish assays) of trace element co-doped hydroxyapatite combined with Mn-Zn ferrite for bone tissue applications.

Tithito T, Sillapaprayoon S, Chantho V, Pimtong W, Thongbunchoo J, Charoenphandhu N RSC Adv. 2024; 14(40):29242-29253.

PMID: 39285891 PMC: 11404014. DOI: 10.1039/d4ra03867c.

Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine.

Inam H, Sprio S, Tavoni M, Abbas Z, Pupilli F, Tampieri A Int J Mol Sci. 2024; 25(5).

PMID: 38474056 PMC: 10932331. DOI: 10.3390/ijms25052809.

Antibiotic photocatalysis and antimicrobial activity of low-cost multifunctional FeO@HAp nanocomposites.

Labrag J, Abbadi M, Hnini M, Bekkali C, Bouziani A, Robert D J Environ Health Sci Eng. 2023; 21(2):429-440.

PMID: 37869605 PMC: 10584758. DOI: 10.1007/s40201-023-00869-8.

Bio-Inspired Nanomaterials for Micro/Nanodevices: A New Era in Biomedical Applications.

Harun-Ur-Rashid M, Jahan I, Foyez T, Imran A Micromachines (Basel). 2023; 14(9).

PMID: 37763949 PMC: 10536921. DOI: 10.3390/mi14091786.

References

Zhu Y, Yang Q, Yang M, Zhan X, Lan F, He J . Protein Corona of Magnetic Hydroxyapatite Scaffold Improves Cell Proliferation via Activation of Mitogen-Activated Protein Kinase Signaling Pathway. ACS Nano. 2017; 11(4):3690-3704. DOI: 10.1021/acsnano.6b08193. View

Elsherbini A, Saber M, Aggag M, El-Shahawy A, Shokier H . Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites. Int J Nanomedicine. 2011; 6:2155-65. PMC: 3215156. DOI: 10.2147/IJN.S23952. View

Kumar A, Nune K, Basu B, Misra R . Mechanistic contribution of electroconductive hydroxyapatite-titanium disilicide composite on the alignment and proliferation of cells. J Biomater Appl. 2016; 30(10):1505-16. DOI: 10.1177/0885328216631670. View

Padwal P, Bandyopadhyaya R, Mehra S . Polyacrylic acid-coated iron oxide nanoparticles for targeting drug resistance in mycobacteria. Langmuir. 2014; 30(50):15266-76. DOI: 10.1021/la503808d. View

Abbasi Aval N, Islamian J, Hatamian M, Arabfirouzjaei M, Javadpour J, Rashidi M . Doxorubicin loaded large-pore mesoporous hydroxyapatite coated superparamagnetic Fe3O4 nanoparticles for cancer treatment. Int J Pharm. 2016; 509(1-2):159-167. DOI: 10.1016/j.ijpharm.2016.05.046. View

Manatunga D, de Silva R, de Silva K, De Silva N, Bhandari S, Yap Y . pH responsive controlled release of anti-cancer hydrophobic drugs from sodium alginate and hydroxyapatite bi-coated iron oxide nanoparticles. Eur J Pharm Biopharm. 2017; 117:29-38. DOI: 10.1016/j.ejpb.2017.03.014. View

Gaihre B, Khil M, Kang H, Kim H . Bioactivity of gelatin coated magnetic iron oxide nanoparticles: in vitro evaluation. J Mater Sci Mater Med. 2008; 20(2):573-81. DOI: 10.1007/s10856-008-3565-4. View

Gambardella A, Bianchi M, Kaciulis S, Mezzi A, Brucale M, Cavallini M . Magnetic hydroxyapatite coatings as a new tool in medicine: A scanning probe investigation. Mater Sci Eng C Mater Biol Appl. 2016; 62:444-9. DOI: 10.1016/j.msec.2016.01.071. View

Iwasaki T, Nakatsuka R, Murase K, Takata H, Nakamura H, Watano S . Simple and rapid synthesis of magnetite/hydroxyapatite composites for hyperthermia treatments via a mechanochemical route. Int J Mol Sci. 2013; 14(5):9365-78. PMC: 3676787. DOI: 10.3390/ijms14059365. View

10.

Mahmoudi M, Serpooshan V . Silver-coated engineered magnetic nanoparticles are promising for the success in the fight against antibacterial resistance threat. ACS Nano. 2012; 6(3):2656-64. DOI: 10.1021/nn300042m. View

11.

Xie W, Zang X . Covalent immobilization of lipase onto aminopropyl-functionalized hydroxyapatite-encapsulated-γ-FeO nanoparticles: A magnetic biocatalyst for interesterification of soybean oil. Food Chem. 2017; 227:397-403. DOI: 10.1016/j.foodchem.2017.01.082. View

12.

Depan D, Misra R . Processing-structure-functional property relationship in organic-inorganic nanostructured scaffolds for bone-tissue engineering: the response of preosteoblasts. J Biomed Mater Res A. 2012; 100(11):3080-91. DOI: 10.1002/jbm.a.34245. View

13.

Iannotti V, Adamiano A, Ausanio G, Lanotte L, Aquilanti G, Coey J . Fe-Doping-Induced Magnetism in Nano-Hydroxyapatites. Inorg Chem. 2017; 56(8):4447-4459. DOI: 10.1021/acs.inorgchem.6b03143. View

14.

Tampieri A, DAlessandro T, Sandri M, Sprio S, Landi E, Bertinetti L . Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite. Acta Biomater. 2011; 8(2):843-51. DOI: 10.1016/j.actbio.2011.09.032. View

15.

Gopi D, Ansari M, Shinyjoy E, Kavitha L . Synthesis and spectroscopic characterization of magnetic hydroxyapatite nanocomposite using ultrasonic irradiation. Spectrochim Acta A Mol Biomol Spectrosc. 2011; 87:245-50. DOI: 10.1016/j.saa.2011.11.047. View

16.

Tran N, Webster T . Increased osteoblast functions in the presence of hydroxyapatite-coated iron oxide nanoparticles. Acta Biomater. 2010; 7(3):1298-306. DOI: 10.1016/j.actbio.2010.10.004. View

17.

Thomas C, Ferris D, Lee J, Choi E, Cho M, Kim E . Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles. J Am Chem Soc. 2010; 132(31):10623-5. DOI: 10.1021/ja1022267. View

18.

Tran N, Webster T . Understanding magnetic nanoparticle osteoblast receptor-mediated endocytosis using experiments and modeling. Nanotechnology. 2013; 24(18):185102. DOI: 10.1088/0957-4484/24/18/185102. View

19.

Guo X, Gough J, Xiao P . Electrophoretic deposition of hydroxyapatite coating on Fecralloy and analysis of human osteoblastic cellular response. J Biomed Mater Res A. 2006; 80(1):24-33. DOI: 10.1002/jbm.a.30857. View

20.

Pan J, Zhang J, Wang L, Wan D . Synthesis of iron oxide coated fluoridated HAp/Ln³⁺ (Ln = Eu or Tb) nanocomposites for biological applications. Chem Commun (Camb). 2014; 50(90):14010-2. DOI: 10.1039/c4cc06977c. View