A Case Report: Is Mexiletine Usage Effective in the Shortening of QTC Interval and Improving the T-wave Alternans in Timothy Syndrome?

Overview

Journal Ann Noninvasive Electrocardiol

Specialty Cardiology & Vascular Diseases

Date 2017 Dec 2

PMID 29194862

Citations 5

Authors

Gulhan Tunca Sahin

Yakup Ergul

Affiliations

Soon will be listed here.

Abstract

Timothy syndrome (TS) is a multisystemic disease that occurs because of a mutation in CACN1C gene and is characterized by prolonged QT interval. Mexiletine is a Class 1B antiarrhythmic drug that causes the disappearance of T-wave alternans by shortening QTc and peak-to-end of the T wave. It may block the development of torsades de pointes in a prolonged QT. This study presented the case of a patient diagnosed with TS and had a cardiac arrest history, prolonged QT, and T-wave alternans. After mexiletine treatment, the QTc interval shortened and T-wave alternans disappeared. Such a case has rarely been seen in the literature, and hence considered rare. This case presentation was of particular importance because it highlighted the use of mexiletine besides an initial beta-blocker treatment in the cases with TS.

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A case report: Is mexiletine usage effective in the shortening of QTC interval and improving the T-wave alternans in Timothy syndrome?.

Tunca Sahin G, Ergul Y Ann Noninvasive Electrocardiol. 2017; 23(3):e12522.

PMID: 29194862 PMC: 6931748. DOI: 10.1111/anec.12522.

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