The POZ/BTB and AT-Hook Containing Zinc Finger 1 (PATZ1) Transcription Regulator: Physiological Functions and Disease Involvement

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2017 Dec 1

PMID 29186807

Citations 16

Authors

Monica Fedele

Elvira Crescenzi

Laura Cerchia

Affiliations

Soon will be listed here.

Abstract

PATZ1 is a zinc finger protein, belonging to the POZ domain Krüppel-like zinc finger (POK) family of architectural transcription factors, first discovered in 2000 by three independent groups. Since that time accumulating evidences have shown its involvement in a variety of biological processes (i.e., embryogenesis, stemness, apoptosis, senescence, proliferation, T-lymphocyte differentiation) and human diseases. Here we summarize these studies with a focus on the PATZ1 emerging and controversial role in cancer, where it acts as either a tumor suppressor or an oncogene. Finally, we give some insight on clinical perspectives using PATZ1 as a prognostic marker and therapeutic target.

Citing Articles

Binding to the Other Side: The AT-Hook DNA-Binding Domain Allows Nuclear Factors to Exploit the DNA Minor Groove.

Battista S, Fedele M, Secco L, Ingo A, Sgarra R, Manfioletti G Int J Mol Sci. 2024; 25(16).

PMID: 39201549 PMC: 11354804. DOI: 10.3390/ijms25168863.

POZ/BTB and AT hook containing zinc finger 1 (PATZ1) suppresses differentiation and regulates metabolism in human embryonic stem cells.

Huang M, Liao X, Wang X, Qian Y, Zhang W, Chen G Int J Biol Sci. 2024; 20(4):1142-1159.

PMID: 38385086 PMC: 10878140. DOI: 10.7150/ijbs.83927.

PATZ1 in Non-Small Cell Lung Cancer: A New Biomarker That Negatively Correlates with PD-L1 Expression and Suppresses the Malignant Phenotype.

Luca S, Franco R, Napolitano A, Soria V, Ronchi A, Marino F Cancers (Basel). 2023; 15(7).

PMID: 37046851 PMC: 10093756. DOI: 10.3390/cancers15072190.

Critical Role of the Transcription Factor AKNA in T-Cell Activation: An Integrative Bioinformatics Approach.

Ramirez-Gonzalez A, Avila-Lopez P, Bahena-Roman M, Contreras-Ochoa C, Lagunas-Martinez A, Langley E Int J Mol Sci. 2023; 24(4).

PMID: 36835622 PMC: 9965657. DOI: 10.3390/ijms24044212.

BTBD10 inhibits glioma tumorigenesis by downregulating cyclin D1 and p-Akt.

Liu Y, Li S, Chen R, Chen J, Xiao B, Lu Y Open Life Sci. 2022; 17(1):907-916.

PMID: 36045715 PMC: 9372705. DOI: 10.1515/biol-2022-0103.

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