ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Aug 5

PMID 34349770

Citations 42

Authors

Zhong-Yan Cheng

Ting-Ting He

Xiao-Ming Gao

Ying Zhao

Jun Wang

Affiliations

Soon will be listed here.

Abstract

The development and differentiation of T cells represents a long and highly coordinated, yet flexible at some points, pathway, along which the sequential and dynamic expressions of different transcriptional factors play prominent roles at multiple steps. The large ZBTB family comprises a diverse group of transcriptional factors, and many of them have emerged as critical factors that regulate the lineage commitment, differentiation and effector function of hematopoietic-derived cells as well as a variety of other developmental events. Within the T-cell lineage, several ZBTB proteins, including ZBTB1, ZBTB17, ZBTB7B (THPOK) and BCL6 (ZBTB27), mainly regulate the development and/or differentiation of conventional CD4/CD8 αβ T cells, whereas ZBTB16 (PLZF) is essential for the development and function of innate-like unconventional δ T & invariant NKT cells. Given the critical role of T cells in host defenses against infections/tumors and in the pathogenesis of many inflammatory disorders, we herein summarize the roles of fourteen ZBTB family members in the development, differentiation and effector function of both conventional and unconventional T cells as well as the underlying molecular mechanisms.

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