The Role of PET/CT Imaging in Penile Cancer

Overview

Journal Transl Androl Urol

Date 2017 Nov 30

PMID 29184780

Citations 7

Authors

Sarah R Ottenhof

Erik Vegt

Affiliations

Soon will be listed here.

Abstract

Positron emission tomography (PET) imaging with F-fluorodeoxyglucose (FDG) combined with computed tomography (CT) provides functional imaging combined with anatomic information, improving diagnostic accuracy and confidence. Although virtually all primary penile tumors are FDG-avid, PET/CT is not recommended for primary tumor staging as it has limited spatial resolution and is hampered by urinary FDG excretion. The accuracy of PET/CT for lymph node staging seems to improve with the pretest likelihood of metastatic nodes. In groins with normal physical examination, sensitivity is only 57%. In groins with palpably enlarged lymph nodes, sensitivity of PET/CT reaches 96%. For pelvic lymph nodes and distant metastases, PET/CT is more accurate if inguinal metastases are present. However, these results are based on a very limited number of studies. Overall, the role of PET/CT imaging in penile cancer remains ambiguous, especially in inguinal lymph nodes. During staging and follow-up, it may be particularly useful in detecting pelvic lymph node metastases and occult distant metastases prior to systemic chemotherapy and/or extensive surgery, improving selection of patients that are most likely to benefit from such therapies.

Citing Articles

Current Role of PET CT in Staging and Management of Penile Cancers.

Mirvald C, Garaz R, Sinescu I, Preda A, Labanaris A, Yossepowitch O J Clin Med. 2024; 13(16).

PMID: 39201021 PMC: 11355205. DOI: 10.3390/jcm13164879.

PET-CT in Clinical Adult Oncology-IV. Gynecologic and Genitourinary Malignancies.

Salem A, Fine G, Covington M, Koppula B, Wiggins R, Hoffman J Cancers (Basel). 2022; 14(12).

PMID: 35740665 PMC: 9220973. DOI: 10.3390/cancers14123000.

Carcinoma Penis Manifesting as Upfront Supraclavicular Lymph Node Metastases Detected by F-Fluorodeoxyglucose Positron Emission Tomography Scan: Report of an Extremely Rare and Aggressive Case.

Purkayastha A, Suhag V, Taneja S, Husain A World J Nucl Med. 2022; 21(1):76-79.

PMID: 35502278 PMC: 9056121. DOI: 10.1055/s-0042-1748155.

Carcinoma penis manifesting as upfront supraclavicular lymph node metastases detected by F-fluorodeoxyglucose positron emission tomography scan: Report of an extremely rare and aggressive case.

Purkayastha A, Suhag V, Taneja S, Husain A World J Nucl Med. 2022; 20(4):379-381.

PMID: 35018155 PMC: 8686747. DOI: 10.4103/wjnm.wjnm_74_21.

Prognostic predictors of lymph node metastasis in penile cancer: a systematic review.

Zekan D, Dahman A, Hajiran A, Luchey A, Chahoud J, Spiess P Int Braz J Urol. 2021; 47(5):943-956.

PMID: 33650835 PMC: 8321459. DOI: 10.1590/S1677-5538.IBJU.2020.0959.

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