Experimental Zika Virus Infection of Neotropical Primates

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2017 Nov 29

PMID 29182145

Citations 29

Authors

John A Vanchiere

Julio C Ruiz

Alan G Brady

Thomas J Kuehl

Lawrence E Williams

Wallace B Baze

Gregory K Wilkerson

Pramod N Nehete

Gloria B McClure

Donna L Rogers

Shannan L Rossi

Sasha R Azar

Christopher M Roundy

Scott C Weaver

Nikos Vasilakis

Joe H Simmons

Christian R Abee

Affiliations

Soon will be listed here.

Abstract

The establishment of a sylvatic reservoir of Zika virus (ZIKV) in the Americas is dependent on the susceptibility of primates of sufficient population density, the duration and magnitude of viremia, and their exposure to the human mosquito-borne transmission cycle. To assess the susceptibility of squirrel ( sp.) and owl monkeys ( sp.) to infection, we inoculated four animals of each species with ZIKV from the current epidemic. Viremia in the absence of detectible disease was observed in both species and seroconversion occurred by day 28. ZIKV was detected in the spleen of three owl monkeys: one at 7 days postinoculation (dpi) and two at 14 dpi. This study confirms the susceptibility to ZIKV infection of two Neotropical primate species that live in close proximity to humans in South America, suggesting that they could support a widespread sylvatic ZIKV cycle there. Collectively, establishment of a ZIKV sylvatic transmission cycle in South America would imperil eradication efforts and could provide a mechanism for continued exposure of humans to ZIKV infection and disease.

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