Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research

Overview

Journal Nano Lett

Publisher American Chemical Society

Specialty Biotechnology

Date 2017 Nov 28

PMID 29178811

Citations 47

Authors

Andrew W Holle

Jennifer L Young

Krystyn J Van Vliet

Roger D Kamm

Dennis Discher

Paul Janmey

Joachim P Spatz

Taher Saif

Affiliations

Soon will be listed here.

Abstract

Extracellular biophysical cues have a profound influence on a wide range of cell behaviors, including growth, motility, differentiation, apoptosis, gene expression, adhesion, and signal transduction. Cells not only respond to definitively mechanical cues from the extracellular matrix (ECM) but can also sometimes alter the mechanical properties of the matrix and hence influence subsequent matrix-based cues in both physiological and pathological processes. Interactions between cells and materials in vitro can modify cell phenotype and ECM structure, whether intentionally or inadvertently. Interactions between cell and matrix mechanics in vivo are of particular importance in a wide variety of disorders, including cancer, central nervous system injury, fibrotic diseases, and myocardial infarction. Both the in vitro and in vivo effects of this coupling between mechanics and biology hold important implications for clinical applications.

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