Transcatheter or Surgical Aortic Valve Replacement in Patients with Advanced Kidney Disease: A Propensity Score-matched Analysis

Overview

Journal Clin Cardiol

Specialty Cardiology & Vascular Diseases

Date 2017 Nov 23

PMID 29166543

Citations 10

Authors

Rajkumar Doshi

Jay Shah

Vaibhav Patel

Varun Jauhar

Perwaiz Meraj

Affiliations

Soon will be listed here.

Abstract

Background: Transcatheter aortic valve replacement (TAVR) is an alternative for surgically inoperable patients with severe aortic stenosis. Advanced kidney disease may significantly affect outcomes in patients treated with TAVR and surgical aortic valve replacement (SAVR).

Hypothesis: TAVR is associated with better in-hospital outcomes compared with SAVR in patients with advanced kidney disease.

Methods: We identified our sample from the National Inpatient Sample between 2012 and 2014, using International Classification of Diseases, Ninth Revision, Clinical Modification codes. We included patients with chronic kidney disease stages IV and V and end-stage renal disease as advanced kidney disease patients. We excluded patients with acute kidney injury on admission and patients on dialysis.

Results: After propensity matching, 2485 patients were included in each group. The primary outcome of in-hospital mortality (12.9% vs 6.2%; P < 0.01) was higher with SAVR as compared with TAVR. Patients who underwent SAVR reported higher acute kidney injury (50.3% vs 33%; P < 0.01) and dialysis requirements (26.8% vs 20.1%; P < 0.01). Other secondary outcomes including blood transfusion, atrial fibrillation, iatrogenic cardiac complications, pericardial complications, perioperative stroke, perioperative infections, and postoperative shock were more common with SAVR. With SAVR, the length of hospitalization and hospitalization costs were significantly higher; however, permanent pacemaker placement was more common with TAVR compared with SAVR.

Conclusions: In patients with advanced kidney disease, SAVR was associated with higher mortality and higher periprocedural complications, as compared with TAVR. Thus, benefits of TAVR could be extended in patients with advanced kidney disease who cannot undergo surgery.

Citing Articles

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Transcatheter Aortic Valve Replacement (TAVR) Versus Surgical Aortic Valve Replacement (SAVR): A Review on the Length of Stay, Cost, Comorbidities, and Procedural Complications.

Kermanshahchi J, Thind B, Davoodpour G, Hirsch M, Chen J, Reddy A Cureus. 2024; 16(2):e54435.

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Tan E, Lee Y, Kuo Y, Tsao T, Lee K, Hsiung M Front Cardiovasc Med. 2022; 9:973889.

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Propensity matched comparison of TAVI and SAVR in intermediate-risk patients with severe aortic stenosis and moderate-to-severe chronic kidney disease: a subgroup analysis from the German Aortic Valve Registry.

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