CD4T Cell Specific B7-H1 Selectively Inhibits Proliferation of Naïve T Cells and Th17 Differentiation in Experimental Autoimmune Encephalomyelitis

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Nov 23

PMID 29163808

Citations 1

Authors

Sheng-Jia Shi

Mei-Ling Ding

Li-Juan Wang

Jie-Heng Wu

Dong-Hui Han

Guo-Xu Zheng

Zhang-Yan Guo

Wen-Jin Xi

Wei-Jun Qin

An-Gang Yang

Wei-Hong Wen

Affiliations

Soon will be listed here.

Abstract

It is widely acknowledged that interleukin 17-producing T helper (Th17) cells are critically participant in the pathogenesis of multiple sclerosis. In the current study, we identified that the expression of CD4T cells specific co-inhibitory molecule B7-homologue 1(B7-H1) in spleenocytes and mononuclear cells isolated from brains and spinal cord were positive correlated with Th1 and Th17 cells generation and disease severity in experimental autoimmune encephalomyelitis (EAE). Furthermore, B7-H1 transgenic mice developed milder EAE symptoms and fewer Th17 cells than B7-H1 wild type mice. We also found the proliferation of naïve CD4CD62T cells isolated from B7-H1 transgenic mice was inhibited. And naïve T cells isolated from B7-H1 transgenic mice produced fewer Th17 cells than WT mice in Th17-polarizing conditions, but the Th1, Th2, and inducible Treg differentiation were the similar in naïve T cells isolated from B7-H1 transgenic mice and WT mice. In conclusion, our study show CD4T cells specific B7-H1 is a slective inhibitor in proliferation of naïve T cells, Th17 differentiation and pathogenesis of multiple sclerosis.

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