The Association Between Artificial Sweeteners and Obesity

Overview

Journal Curr Gastroenterol Rep

Specialty Gastroenterology

Date 2017 Nov 22

PMID 29159583

Citations 57

Authors

Michelle Pearlman

Jon Obert

Lisa Casey

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: The purpose of this paper is to review the epidemiology of obesity and the evolution of artificial sweeteners; to examine the latest research on the effects of artificial sweeteners on the host microbiome, the gut-brain axis, glucose homeostasis, and energy consumption; and to discuss how all of these changes ultimately contribute to obesity.

Recent Findings: Although artificial sweeteners were developed as a sugar substitute to help reduce insulin resistance and obesity, data in both animal models and humans suggest that the effects of artificial sweeteners may contribute to metabolic syndrome and the obesity epidemic. Artificial sweeteners appear to change the host microbiome, lead to decreased satiety, and alter glucose homeostasis, and are associated with increased caloric consumption and weight gain. Artificial sweeteners are marketed as a healthy alternative to sugar and as a tool for weight loss. Data however suggests that the intended effects do not correlate with what is seen in clinical practice. Future research should focus on the newer plant-based sweeteners, incorporate extended study durations to determine the long-term effects of artificial sweetener consumption, and focus on changes in the microbiome, as that seems to be one of the main driving forces behind nutrient absorption and glucose metabolism.

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References

Black R, Leiter L, Anderson G . Consuming aspartame with and without taste: differential effects on appetite and food intake of young adult males. Physiol Behav. 1993; 53(3):459-66. DOI: 10.1016/0031-9384(93)90139-7. View

Swithers S, Laboy A, Clark K, Cooper S, Davidson T . Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats. Behav Brain Res. 2012; 233(1):1-14. PMC: 3378816. DOI: 10.1016/j.bbr.2012.04.024. View

Stice E, Spoor S, Bohon C, Veldhuizen M, Small D . Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study. J Abnorm Psychol. 2008; 117(4):924-35. PMC: 2681092. DOI: 10.1037/a0013600. View

Backhed F, Ding H, Wang T, Hooper L, Koh G, Nagy A . The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004; 101(44):15718-23. PMC: 524219. DOI: 10.1073/pnas.0407076101. View

Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F . A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012; 490(7418):55-60. DOI: 10.1038/nature11450. View

Shankar P, Ahuja S, Sriram K . Non-nutritive sweeteners: review and update. Nutrition. 2013; 29(11-12):1293-9. DOI: 10.1016/j.nut.2013.03.024. View

Ganchrow J, STEINER J, Canetto S . Behavioral displays to gustatory stimuli in newborn rat pups. Dev Psychobiol. 1986; 19(3):163-74. DOI: 10.1002/dev.420190303. View

Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss C, Maza O . Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014; 514(7521):181-6. DOI: 10.1038/nature13793. View

Sclafani A . Sweet taste signaling in the gut. Proc Natl Acad Sci U S A. 2007; 104(38):14887-8. PMC: 1986582. DOI: 10.1073/pnas.0707410104. View

10.

De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet J, Massart S . Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A. 2010; 107(33):14691-6. PMC: 2930426. DOI: 10.1073/pnas.1005963107. View

11.

Segata N . Gut Microbiome: Westernization and the Disappearance of Intestinal Diversity. Curr Biol. 2015; 25(14):R611-3. DOI: 10.1016/j.cub.2015.05.040. View

12.

MAZUR R, GOLDKAMP A, James P, Schlatter J . Structure-taste relationships of aspartic acid amides. J Med Chem. 1970; 13(6):1217-21. DOI: 10.1021/jm00300a046. View

13.

Fowler S, Williams K, Resendez R, Hunt K, Hazuda H, Stern M . Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain. Obesity (Silver Spring). 2008; 16(8):1894-900. DOI: 10.1038/oby.2008.284. View

14.

Yang Q . Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010. Yale J Biol Med. 2010; 83(2):101-8. PMC: 2892765. View

15.

Ley R, Backhed F, Turnbaugh P, Lozupone C, Knight R, Gordon J . Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A. 2005; 102(31):11070-5. PMC: 1176910. DOI: 10.1073/pnas.0504978102. View

16.

Turnbaugh P, Ley R, Mahowald M, Magrini V, Mardis E, Gordon J . An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444(7122):1027-31. DOI: 10.1038/nature05414. View

17.

Wu T, Zhao B, Bound M, Checklin H, Bellon M, Little T . Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. Am J Clin Nutr. 2011; 95(1):78-83. DOI: 10.3945/ajcn.111.021543. View

18.

Porikos K, Booth G, Van Itallie T . Effect of covert nutritive dilution on the spontaneous food intake of obese individuals: a pilot study. Am J Clin Nutr. 1977; 30(10):1638-44. DOI: 10.1093/ajcn/30.10.1638. View

19.

Gul S, Hamilton A, Munoz A, Phupitakphol T, Liu W, Hyoju S . Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice. Appl Physiol Nutr Metab. 2016; 42(1):77-83. PMC: 5686455. DOI: 10.1139/apnm-2016-0346. View

20.

Xu J, Bjursell M, Himrod J, Deng S, Carmichael L, Chiang H . A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science. 2003; 299(5615):2074-6. DOI: 10.1126/science.1080029. View