Physical Activity in the Prevention of Human Diseases: Role of Epigenetic Modifications

Overview

Journal BMC Genomics

Publisher Biomed Central

Specialty Genetics

Date 2017 Nov 17

PMID 29143608

Citations 79

Authors

Elisa Grazioli

Ivan Dimauro

Neri Mercatelli

Guan Wang

Yannis Pitsiladis

Luigi Di Luigi

Daniela Caporossi

Affiliations

Soon will be listed here.

Abstract

Epigenetic modification refers to heritable changes in gene function that cannot be explained by alterations in the DNA sequence. The current literature clearly demonstrates that the epigenetic response is highly dynamic and influenced by different biological and environmental factors such as aging, nutrient availability and physical exercise. As such, it is well accepted that physical activity and exercise can modulate gene expression through epigenetic alternations although the type and duration of exercise eliciting specific epigenetic effects that can result in health benefits and prevent chronic diseases remains to be determined. This review highlights the most significant findings from epigenetic studies involving physical activity/exercise interventions known to benefit chronic diseases such as metabolic syndrome, diabetes, cancer, cardiovascular and neurodegenerative diseases.

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References

Beltran Valls M, Dimauro I, Brunelli A, Tranchita E, Ciminelli E, Caserotti P . Explosive type of moderate-resistance training induces functional, cardiovascular, and molecular adaptations in the elderly. Age (Dordr). 2013; 36(2):759-72. PMC: 4039278. DOI: 10.1007/s11357-013-9584-1. View

Zimmer P, Baumann F, Bloch W, Schenk A, Koliamitra C, Jensen P . Impact of exercise on pro inflammatory cytokine levels and epigenetic modulations of tumor-competitive lymphocytes in Non-Hodgkin-Lymphoma patients-randomized controlled trial. Eur J Haematol. 2014; 93(6):527-32. DOI: 10.1111/ejh.12395. View

Yao B, Christian K, He C, Jin P, Ming G, Song H . Epigenetic mechanisms in neurogenesis. Nat Rev Neurosci. 2016; 17(9):537-49. PMC: 5610421. DOI: 10.1038/nrn.2016.70. View

Liu J, Chen J, Ehrlich S, Walton E, White T, Perrone-Bizzozero N . Methylation patterns in whole blood correlate with symptoms in schizophrenia patients. Schizophr Bull. 2013; 40(4):769-76. PMC: 4059425. DOI: 10.1093/schbul/sbt080. View

Puddu G, Cravero E, Arnone G, Muscari A, Puddu P . Molecular aspects of atherogenesis: new insights and unsolved questions. J Biomed Sci. 2005; 12(6):839-53. DOI: 10.1007/s11373-005-9024-z. View

Beltran Valls M, Wilkinson D, Narici M, Smith K, Phillips B, Caporossi D . Protein carbonylation and heat shock proteins in human skeletal muscle: relationships to age and sarcopenia. J Gerontol A Biol Sci Med Sci. 2014; 70(2):174-81. PMC: 4301601. DOI: 10.1093/gerona/glu007. View

Feil R, Fraga M . Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet. 2012; 13(2):97-109. DOI: 10.1038/nrg3142. View

Lee I, Shiroma E, Lobelo F, Puska P, Blair S, Katzmarzyk P . Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet. 2012; 380(9838):219-29. PMC: 3645500. DOI: 10.1016/S0140-6736(12)61031-9. View

Garber C, Blissmer B, Deschenes M, Franklin B, LaMonte M, Lee I . American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011; 43(7):1334-59. DOI: 10.1249/MSS.0b013e318213fefb. View

10.

Isanejad A, Alizadeh A, Amani Shalamzari S, Khodayari H, Khodayari S, Khori V . MicroRNA-206, let-7a and microRNA-21 pathways involved in the anti-angiogenesis effects of the interval exercise training and hormone therapy in breast cancer. Life Sci. 2016; 151:30-40. DOI: 10.1016/j.lfs.2016.02.090. View

11.

Portela A, Esteller M . Epigenetic modifications and human disease. Nat Biotechnol. 2010; 28(10):1057-68. DOI: 10.1038/nbt.1685. View

12.

Sigal R, Kenny G, Boule N, Wells G, Prudhomme D, Fortier M . Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med. 2007; 147(6):357-69. DOI: 10.7326/0003-4819-147-6-200709180-00005. View

13.

Rice J, Allis C . Histone methylation versus histone acetylation: new insights into epigenetic regulation. Curr Opin Cell Biol. 2001; 13(3):263-73. DOI: 10.1016/s0955-0674(00)00208-8. View

14.

Rodriguez J, Frigola J, Vendrell E, Risques R, Fraga M, Morales C . Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res. 2006; 66(17):8462-9468. DOI: 10.1158/0008-5472.CAN-06-0293. View

15.

Yuasa Y, Nagasaki H, Akiyama Y, Hashimoto Y, Takizawa T, Kojima K . DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients. Int J Cancer. 2009; 124(11):2677-82. DOI: 10.1002/ijc.24231. View

16.

He L, Thomson J, Hemann M, Hernando-Monge E, Mu D, Goodson S . A microRNA polycistron as a potential human oncogene. Nature. 2005; 435(7043):828-33. PMC: 4599349. DOI: 10.1038/nature03552. View

17.

Cummins J, He Y, Leary R, Pagliarini R, Diaz Jr L, Sjoblom T . The colorectal microRNAome. Proc Natl Acad Sci U S A. 2006; 103(10):3687-92. PMC: 1450142. DOI: 10.1073/pnas.0511155103. View

18.

Keller P, Vollaard N, Gustafsson T, Gallagher I, Sundberg C, Rankinen T . A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. J Appl Physiol (1985). 2010; 110(1):46-59. PMC: 3253010. DOI: 10.1152/japplphysiol.00634.2010. View

19.

Ichimura A, Ruike Y, Terasawa K, Tsujimoto G . miRNAs and regulation of cell signaling. FEBS J. 2011; 278(10):1610-8. DOI: 10.1111/j.1742-4658.2011.08087.x. View

20.

Bryan A, Magnan R, Hooper A, Harlaar N, Hutchison K . Physical activity and differential methylation of breast cancer genes assayed from saliva: a preliminary investigation. Ann Behav Med. 2012; 45(1):89-98. PMC: 3548059. DOI: 10.1007/s12160-012-9411-4. View