Safety and Feasibility Study of Holmium Laser Enucleation of the Prostate (HOLEP) on Patients Receiving Dual Antiplatelet Therapy (DAPT)

Overview

Journal World J Urol

Specialty Urology

Date 2017 Nov 16

PMID 29138929

Citations 11

Authors

Jie Sun

An Shi

Zhen Tong

Wei Xue

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the safety and feasibility of Holmium laser enucleation of the prostate (HoLEP) in patients receiving dual antiplatelet therapy (DAPT).

Methods: From March 2013 to August 2016, we retrospectively analyzed 1124 benign prostatic hyperplasia (BPH) patients undergoing HoLEP and divided into four groups: 56 cases receiving DAPT therapy (group A); 72 patients treated with continuous single antiplatelet (AP) therapy (group B); 41 patients treated with single AP therapy but intermittent during preoperative time (group C) and 955 cases had no AP therapy (group D). Patients' baseline characteristics, 1-year clinical outcomes, rates of postoperative bleeding and complications were presented in this study.

Results: All patients received successful operations and no severe postoperative complications occurred. Only one patient in Group D required transfusion. The enucleation time and catheterization time for the DAPT patients were the longest among four groups (p < 0.001, respectively). The overall complications rates within 30 days were 23.2% (13/56) in Group A, 27.8% (20/72) in Group B, 19.5% (8/41) in Group C, and 27.0% (258/955) in Group D, respectively (p = 0.678). By the 12 months, the international prostate symptom scores (IPSS), quality of life scores (QOL) and residual urine volume (RUV) in all groups have been significantly improved.

Conclusion: HoLEP in patients receiving DAPT after coronary artery stunting showed similar results to those achieved in patients receiving single AP therapy or non-AP therapy. It can be a good option, which the urologists can offer to those patients with symptomatic benign prostatic hyperplasia refractory to medical treatment.

Citing Articles

Early Hemorrhagic Complications after Holmium Laser Enucleation of the Prostate in Patients Undergoing Antithrombotic Therapy: A Retrospective Analysis from a High-Volume Centre.

Pastore S, Carilli M, Di Nicola S, Campagna A, Parente U, Pierella F J Clin Med. 2024; 13(19).

PMID: 39408065 PMC: 11478196. DOI: 10.3390/jcm13196006.

Thromboelastography in Long-Term Antiplatelet Therapy for Patients Diagnosed with Benign Prostate Hyperplasia Undergoing Holmium Laser Enucleation of the Prostate: A Retrospective Study.

Gu Z, Qiu L, Zhu H, Lu M, Chen J Ther Clin Risk Manag. 2024; 20:633-639.

PMID: 39280636 PMC: 11402346. DOI: 10.2147/TCRM.S472153.

Patient reported outcome and quality of life measured by a simple questionnaire in patients with symptomatic benign prostate hyperplasia treated by holmium laser enucleation of the prostate (HoLEP).

Schumacher S, Marghawal D, Brunken C, Herzberg J Front Surg. 2024; 11:1358701.

PMID: 38389860 PMC: 10881724. DOI: 10.3389/fsurg.2024.1358701.

Thulium fiber laser vs. holmium laser enucleation of the prostate: results of a prospective randomized non-inferiority trial.

Kosiba M, Filzmayer M, Welte M, Hugenell L, Keller A, Traumann M World J Urol. 2024; 42(1):49.

PMID: 38244076 PMC: 10799774. DOI: 10.1007/s00345-023-04748-7.

Holmium laser enucleation of the prostate (HoLEP) is safe and effective in patients with high comorbidity burden.

Di Maida F, Grosso A, Tellini R, Nardoni S, Giudici S, Cadenar A Int Braz J Urol. 2023; 49(3):341-350.

PMID: 36794848 PMC: 10335890. DOI: 10.1590/S1677-5538.IBJU.2022.0174.

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