[Relationship Between Serum 25(OH)D Levels at Birth and Respiratory Distress Syndrome in Preterm Infants]

Overview

Journal Zhongguo Dang Dai Er Ke Za Zhi

Specialty Pediatrics

Date 2017 Nov 15

PMID 29132457

Citations 3

Authors

Ren-Qiang Yu

Dao-Zhen Chen

Xiao-Qing Hao

Shi-Hong Jiang

Guang-Dong Fang

Qin Zhou

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels at birth and respiratory distress syndrome (RDS) in preterm infants.

Methods: This retrospective study recruited preterm infants with gestational age of below 34 weeks who were born between January 2014 and December 2016. These preterm infants were divided into two groups: RDS (n=72) and control (n=40). Clinical data of the two groups were collected, including gestational age, birth weight, gender, delivery mode, Apgar scores at 1 minute and 5 minutes, incidence of maternal gestational diabetes mellitus, and use of prenatal steroid hormone. Peripheral blood samples were collected and 25(OH)D levels were measured by chemiluminescence immunoassay. The association between serum 25(OH)D levels at birth and RDS was analyzed by multivariate logistic regression.

Results: Apgar scores at 1 minute and 5 minutes and serum 25(OH)D levels in the RDS group were significantly lower than those in the control group (P<0.05), while the rates of neonatal asphyxia and vitamin D deficiency were significantly higher than those in the control group (P<0.05). Multivariate logistic regression analysis showed that neonatal asphyxia (OR=2.633, 95%CI: 1.139-6.085) and vitamin D deficiency (OR=4.064, 95%CI: 1.625-10.165) were risk factors for RDS in preterm infants.

Conclusions: Vitamin D deficiency might be associated with increased risk of RDS in preterm infants. Reasonable vitamin D supplementation during pregnancy might reduce the incidence of RDS in preterm infants.

Citing Articles

Unveiling the Novel Impact of Vitamin D Injections at Birth on the Prognosis of Newborns: A Double-blind Study.

Boskabadi H, Sadeghi T, Mostafavi M Oman Med J. 2025; 39(4):e650.

PMID: 39967898 PMC: 11833769. DOI: 10.5001/omj.2024.89.

Association between vitamin D level and respiratory distress syndrome: A systematic review and meta-analysis.

Kim Y, Lim G, Lee R, Chung S, Son J, Park H PLoS One. 2023; 18(1):e0279064.

PMID: 36701289 PMC: 9879443. DOI: 10.1371/journal.pone.0279064.

Association Between Vitamin D Level and Neonatal Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis.

Zang R, Zhang Y, Zhang H, Zhang X, Lv Y, Li D Front Pediatr. 2022; 9:803143.

PMID: 35127597 PMC: 8815315. DOI: 10.3389/fped.2021.803143.

Vitamin D deficiency and its effect on respiratory distress syndrome in premature infants: results from a prospective study in a tertiary care centre.

Dogan P, Ozkan H, Koksal N, Bagci O, Guney Varal I Afr Health Sci. 2021; 20(1):437-443.

PMID: 33402932 PMC: 7750057. DOI: 10.4314/ahs.v20i1.50.

References

Lykkedegn S, Sorensen G, Beck-Nielsen S, Christesen H . The impact of vitamin D on fetal and neonatal lung maturation. A systematic review. Am J Physiol Lung Cell Mol Physiol. 2015; 308(7):L587-602. DOI: 10.1152/ajplung.00117.2014. View

Yu R, Zhao X, Chen D, Liao X, Zhou Q . [Vitamin D level at birth and influencing factors in preterm infants]. Zhongguo Dang Dai Er Ke Za Zhi. 2017; 19(7):800-805. PMC: 7389922. View

Taylor S, Sakurai R, Sakurai T, Rehan V . Inhaled Vitamin D: A Novel Strategy to Enhance Neonatal Lung Maturation. Lung. 2016; 194(6):931-943. PMC: 5191914. DOI: 10.1007/s00408-016-9939-3. View

Saadoon A, Ambalavanan N, Zinn K, Ashraf A, MacEwen M, Nicola T . Effect of Prenatal versus Postnatal Vitamin D Deficiency on Pulmonary Structure and Function in Mice. Am J Respir Cell Mol Biol. 2016; 56(3):383-392. PMC: 5359534. DOI: 10.1165/rcmb.2014-0482OC. View

Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R . Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-30. DOI: 10.1210/jc.2011-0385. View

Cetinkaya M, Cekmez F, Erener-Ercan T, Buyukkale G, Demirhan A, Aydemir G . Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?. J Perinatol. 2015; 35(10):813-7. DOI: 10.1038/jp.2015.88. View

Fettah N, Zenciroglu A, Dilli D, Beken S, Okumus N . Is higher 25-hydroxyvitamin D level preventive for respiratory distress syndrome in preterm infants?. Am J Perinatol. 2014; 32(3):247-50. DOI: 10.1055/s-0034-1383849. View

Lykkedegn S, Sorensen G, Beck-Nielsen S, Pilecki B, Duelund L, Marcussen N . Vitamin D Depletion in Pregnancy Decreases Survival Time, Oxygen Saturation, Lung Weight and Body Weight in Preterm Rat Offspring. PLoS One. 2016; 11(8):e0155203. PMC: 5003352. DOI: 10.1371/journal.pone.0155203. View

Mandell E, Seedorf G, Gien J, Abman S . Vitamin D treatment improves survival and infant lung structure after intra-amniotic endotoxin exposure in rats: potential role for the prevention of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014; 306(5):L420-8. PMC: 3949057. DOI: 10.1152/ajplung.00344.2013. View

10.

Sava F, Treszl A, Hajdu J, Toldi G, Rigo Jr J, Tulassay T . Plasma vitamin D levels at birth and immune status of preterm infants. Immunobiology. 2016; 221(11):1289-92. DOI: 10.1016/j.imbio.2016.06.001. View

11.

Konstantinopoulou S, Tapia I . Vitamin D and the lung. Paediatr Respir Rev. 2016; 24:39-43. DOI: 10.1016/j.prrv.2016.10.009. View

12.

Zhao Q, Zhao Z, Leung-Pineda V, Wiley C, Nelson P, Grenache D . Predicting respiratory distress syndrome using gestational age and lamellar body count. Clin Biochem. 2013; 46(13-14):1228-32. DOI: 10.1016/j.clinbiochem.2013.03.020. View

13.

Kovacs C . Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies. Am J Clin Nutr. 2008; 88(2):520S-528S. DOI: 10.1093/ajcn/88.2.520S. View

14.

Dinlen N, Zenciroglu A, Beken S, Dursun A, Dilli D, Okumus N . Association of vitamin D deficiency with acute lower respiratory tract infections in newborns. J Matern Fetal Neonatal Med. 2015; 29(6):928-32. DOI: 10.3109/14767058.2015.1023710. View

15.

Cizmeci M, Kanburoglu M, Akelma A, Ayyildiz A, Kutukoglu I, Malli D . Cord-blood 25-hydroxyvitamin D levels and risk of early-onset neonatal sepsis: a case-control study from a tertiary care center in Turkey. Eur J Pediatr. 2014; 174(6):809-15. DOI: 10.1007/s00431-014-2469-1. View

16.

Nguyen M, Trubert C, Rizk-Rabin M, Rehan V, BESANCON F, Cayre Y . 1,25-Dihydroxyvitamin D3 and fetal lung maturation: immunogold detection of VDR expression in pneumocytes type II cells and effect on fructose 1,6 bisphosphatase. J Steroid Biochem Mol Biol. 2004; 89-90(1-5):93-7. DOI: 10.1016/j.jsbmb.2004.03.054. View

17.

Yurt M, Liu J, Sakurai R, Gong M, Husain S, Siddiqui M . Vitamin D supplementation blocks pulmonary structural and functional changes in a rat model of perinatal vitamin D deficiency. Am J Physiol Lung Cell Mol Physiol. 2014; 307(11):L859-67. PMC: 4254963. DOI: 10.1152/ajplung.00032.2014. View

18.

Agrawal T, Gupta G, Agrawal D . Vitamin D deficiency decreases the expression of VDR and prohibitin in the lungs of mice with allergic airway inflammation. Exp Mol Pathol. 2012; 93(1):74-81. PMC: 3410542. DOI: 10.1016/j.yexmp.2012.04.004. View